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235  structures 542  species 0  interactions 17861  sequences 312  architectures

Clan: GF_recep_C-rich (CL0547)


Growth factor receptor Cys-rich Add an annotation

The cysteine-rich regions of growth factor receptor tyrosine kinases consist of eight disulphide-linked modules [1].

This clan contains 5 families and the total number of domains in the clan is 17861. The clan was built by R Eberhardt.

Literature references

  1. Garrett TP, McKern NM, Lou M, Frenkel MJ, Bentley JD, Lovrecz GO, Elleman TC, Cosgrove LJ, Ward CW; , Nature 1998;394:395-399.: Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor. PUBMED:9690478 EPMC:9690478


This clan contains the following 5 member families:

amfpi-1 Furin-like Furin-like_2 GF_recep_IV IGFBP

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
IGFBP (PF00219) 6194 (34.7%) View
Furin-like (PF00757) 5336 (29.9%) View
GF_recep_IV (PF14843) 4663 (26.1%) View
Furin-like_2 (PF15913) 1637 (9.2%) View
amfpi-1 (PF12190) 31 (0.2%) View
Total: 5 Total: 17861 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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