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60  structures 1527  species 0  interactions 44234  sequences 2205  architectures

Clan: Gain (CL0661)


GPCR autoproteolysis inducing Add an annotation

Members of this clan belong to GAIN domain with an autoproteolytic motif. The G-protein-coupled receptor (GPCR) autoproteolysis-inducing (GAIN) domain, includes GPCRs involved in adhesion with a characteristic autoproteolysis motif of HLT/S known as the GPCR proteolysis site (GPS). GPS is also shared by polycystic kidney disease (PKD) proteins. GAIN has been shown to be both necessary and sufficient for autoproteolysis [1].

This clan contains 6 families and the total number of domains in the clan is 44234. The clan was built by S El-Gebali.

Literature references

  1. Liao Y, Pei J, Cheng H, Grishin NV;, J Mol Biol. 2014;426:3935-3945.: An ancient autoproteolytic domain found in GAIN, ZU5 and Nucleoporin98. PUBMED:25451782 EPMC:25451782


This clan contains the following 6 member families:

DUF1191 GAIN GPS Nucleoporin2 UPF0560 ZU5

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
GPS (PF01825) 17360 (39.2%) View
ZU5 (PF00791) 12790 (28.9%) View
GAIN (PF16489) 8734 (19.7%) View
Nucleoporin2 (PF04096) 2782 (6.3%) View
UPF0560 (PF10577) 1616 (3.7%) View
DUF1191 (PF06697) 952 (2.2%) View
Total: 6 Total: 44234 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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