Summary
Galactose Mutarotase-like superfamily
This clan is composed of a beta-sandwich that was first observed in domain 5 of beta-galactosidase, then as the central domain of copper amine oxidase, the C-terminal domain of chondroitinase, the C-terminal domain of hyaluronate lyase, the N-terminal domain of maltose phosphorylase and in Galactose Mutarotase [1]. All these enzymes act on a sugar substrate.
This clan contains 32 families and the total number of domains in the clan is 106637. The clan was built by A Bateman.
Literature references
- Thoden JB, Holden HM; , J Biol Chem 2002;277:20854-20861.: High resolution X-ray structure of galactose mutarotase from Lactococcus lactis. PUBMED:11907040 EPMC:11907040
Members
This clan contains the following 32 member families:
AGL_N Aldose_epim AmyA-gluTrfs_C Bgal_small_N Cu_amine_oxid DUF4432 DUF4450 DUF5054 DUF5107 DUF5127 DUF5703_N Gal_mutarotas_2 Gal_mutarotas_3 GH97_N Glucodextran_N Glyco_hyd_65N_2 Glyco_hydr_116N Glyco_hydro_36N Glyco_hydro_38 Glyco_hydro_38C Glyco_hydro_52 Glyco_hydro_65N Glyco_hydro_81 Glyco_hydro_92N Glyco_transf_36 Hepar_II_III Lyase_8 MdoG NtCtMGAM_N Rhamnogal_lyase RhgB_N YidC_periplasExternal database links
| SCOP: | 74650 |
Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
| Pfam family | Num. domains | Alignment |
|---|---|---|
| Aldose_epim (PF01263) | 17682 (16.6%) | View |
| Gal_mutarotas_2 (PF13802) | 10844 (10.2%) | View |
| Glyco_hydro_38C (PF07748) | 8794 (8.2%) | View |
| Glyco_hydro_92N (PF17678) | 7273 (6.8%) | View |
| Cu_amine_oxid (PF01179) | 7217 (6.8%) | View |
| NtCtMGAM_N (PF16863) | 4963 (4.7%) | View |
| Hepar_II_III (PF07940) | 4816 (4.5%) | View |
| Bgal_small_N (PF02929) | 4696 (4.4%) | View |
| Glyco_hyd_65N_2 (PF14498) | 4643 (4.4%) | View |
| YidC_periplas (PF14849) | 4290 (4.0%) | View |
| Glyco_hydro_65N (PF03636) | 3978 (3.7%) | View |
| Glyco_hydro_36N (PF16875) | 3515 (3.3%) | View |
| Glyco_transf_36 (PF06165) | 3237 (3.0%) | View |
| GH97_N (PF14508) | 2525 (2.4%) | View |
| Glyco_hydr_116N (PF12215) | 2443 (2.3%) | View |
| AGL_N (PF16338) | 2173 (2.0%) | View |
| DUF5127 (PF17168) | 1956 (1.8%) | View |
| continued | ||
| Pfam family | Num. domains | Alignment |
|---|---|---|
| MdoG (PF04349) | 1826 (1.7%) | View |
| Glyco_hydro_81 (PF03639) | 1800 (1.7%) | View |
| Rhamnogal_lyase (PF06045) | 1685 (1.6%) | View |
| Lyase_8 (PF02278) | 1631 (1.5%) | View |
| DUF5107 (PF17128) | 963 (0.9%) | View |
| DUF4432 (PF14486) | 955 (0.9%) | View |
| RhgB_N (PF09284) | 692 (0.6%) | View |
| Glucodextran_N (PF09137) | 459 (0.4%) | View |
| Gal_mutarotas_3 (PF18080) | 330 (0.3%) | View |
| DUF5703_N (PF18961) | 277 (0.3%) | View |
| AmyA-gluTrfs_C (PF09095) | 271 (0.3%) | View |
| Glyco_hydro_38 (PF18438) | 241 (0.2%) | View |
| DUF5054 (PF16477) | 183 (0.2%) | View |
| DUF4450 (PF14614) | 142 (0.1%) | View |
| Glyco_hydro_52 (PF03512) | 137 (0.1%) | View |
| Total: 32 | Total: 106637 | Clan alignment |
Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.
Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
Tree controls
HideThis tree shows the occurrence of the domains in this clan across different species. More...
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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