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1432  structures 8391  species 0  interactions 106637  sequences 2394  architectures

Clan: Gal_mutarotase (CL0103)


Galactose Mutarotase-like superfamily Add an annotation

This clan is composed of a beta-sandwich that was first observed in domain 5 of beta-galactosidase, then as the central domain of copper amine oxidase, the C-terminal domain of chondroitinase, the C-terminal domain of hyaluronate lyase, the N-terminal domain of maltose phosphorylase and in Galactose Mutarotase [1]. All these enzymes act on a sugar substrate.

This clan contains 32 families and the total number of domains in the clan is 106637. The clan was built by A Bateman.

Literature references

  1. Thoden JB, Holden HM; , J Biol Chem 2002;277:20854-20861.: High resolution X-ray structure of galactose mutarotase from Lactococcus lactis. PUBMED:11907040 EPMC:11907040


This clan contains the following 32 member families:

AGL_N Aldose_epim AmyA-gluTrfs_C Bgal_small_N Cu_amine_oxid DUF4432 DUF4450 DUF5054 DUF5107 DUF5127 DUF5703_N Gal_mutarotas_2 Gal_mutarotas_3 GH97_N Glucodextran_N Glyco_hyd_65N_2 Glyco_hydr_116N Glyco_hydro_36N Glyco_hydro_38 Glyco_hydro_38C Glyco_hydro_52 Glyco_hydro_65N Glyco_hydro_81 Glyco_hydro_92N Glyco_transf_36 Hepar_II_III Lyase_8 MdoG NtCtMGAM_N Rhamnogal_lyase RhgB_N YidC_periplas

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Aldose_epim (PF01263) 17682 (16.6%) View
Gal_mutarotas_2 (PF13802) 10844 (10.2%) View
Glyco_hydro_38C (PF07748) 8794 (8.2%) View
Glyco_hydro_92N (PF17678) 7273 (6.8%) View
Cu_amine_oxid (PF01179) 7217 (6.8%) View
NtCtMGAM_N (PF16863) 4963 (4.7%) View
Hepar_II_III (PF07940) 4816 (4.5%) View
Bgal_small_N (PF02929) 4696 (4.4%) View
Glyco_hyd_65N_2 (PF14498) 4643 (4.4%) View
YidC_periplas (PF14849) 4290 (4.0%) View
Glyco_hydro_65N (PF03636) 3978 (3.7%) View
Glyco_hydro_36N (PF16875) 3515 (3.3%) View
Glyco_transf_36 (PF06165) 3237 (3.0%) View
GH97_N (PF14508) 2525 (2.4%) View
Glyco_hydr_116N (PF12215) 2443 (2.3%) View
AGL_N (PF16338) 2173 (2.0%) View
DUF5127 (PF17168) 1956 (1.8%) View
Pfam family Num. domains Alignment
MdoG (PF04349) 1826 (1.7%) View
Glyco_hydro_81 (PF03639) 1800 (1.7%) View
Rhamnogal_lyase (PF06045) 1685 (1.6%) View
Lyase_8 (PF02278) 1631 (1.5%) View
DUF5107 (PF17128) 963 (0.9%) View
DUF4432 (PF14486) 955 (0.9%) View
RhgB_N (PF09284) 692 (0.6%) View
Glucodextran_N (PF09137) 459 (0.4%) View
Gal_mutarotas_3 (PF18080) 330 (0.3%) View
DUF5703_N (PF18961) 277 (0.3%) View
AmyA-gluTrfs_C (PF09095) 271 (0.3%) View
Glyco_hydro_38 (PF18438) 241 (0.2%) View
DUF5054 (PF16477) 183 (0.2%) View
DUF4450 (PF14614) 142 (0.1%) View
Glyco_hydro_52 (PF03512) 137 (0.1%) View
Total: 32 Total: 106637 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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