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2  structures 6222  species 0  interactions 17115  sequences 127  architectures

Clan: Glycine-zipper (CL0500)

Summary

Glycine-zipper TM superfamily Add an annotation

This superfamily is characterised by having long glycine-zipper motifs, characteristically GxxxGxxxG [1], often with several contiguous copies. The x following the G is frequently found to be an alanine. This sequence region can be found in both symmetric and non-symmetrical membrane structures, and is relatively common. The fact that such a large fraction of the relatively few known membrane channel structures use the glycine zipper suggests that the sequence motif plays a special role in forming these homo-oligomeric bundles [1].

This clan contains 11 families and the total number of domains in the clan is 17115. The clan was built by P Coggill.

Literature references

  1. Kim S, Jeon TJ, Oberai A, Yang D, Schmidt JJ, Bowie JU;, Proc Natl Acad Sci U S A. 2005;102:14278-14283.: Transmembrane glycine zippers: physiological and pathological roles in membrane proteins. PUBMED:16179394 EPMC:16179394

Members

This clan contains the following 11 member families:

17kDa_Anti_2 DUF1269 DUF3482 DUF456 DUF5061 DUF883_C Gly-zipper_Omp Gly-zipper_OmpA Gly-zipper_YMGG Rick_17kDa_Anti Romo1

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Rick_17kDa_Anti (PF05433) 4774 (27.9%) View
Gly-zipper_Omp (PF13488) 3115 (18.2%) View
DUF456 (PF04306) 2253 (13.2%) View
DUF883_C (PF19029) 1608 (9.4%) View
Romo1 (PF10247) 1427 (8.3%) View
Gly-zipper_YMGG (PF13441) 1308 (7.6%) View
DUF1269 (PF06897) 1058 (6.2%) View
17kDa_Anti_2 (PF16998) 718 (4.2%) View
DUF3482 (PF11981) 492 (2.9%) View
Gly-zipper_OmpA (PF13436) 299 (1.7%) View
DUF5061 (PF16587) 63 (0.4%) View
Total: 11 Total: 17115 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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