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2  structures 6222  species 0  interactions 17115  sequences 127  architectures

Clan: Glycine-zipper (CL0500)


Glycine-zipper TM superfamily Add an annotation

This superfamily is characterised by having long glycine-zipper motifs, characteristically GxxxGxxxG [1], often with several contiguous copies. The x following the G is frequently found to be an alanine. This sequence region can be found in both symmetric and non-symmetrical membrane structures, and is relatively common. The fact that such a large fraction of the relatively few known membrane channel structures use the glycine zipper suggests that the sequence motif plays a special role in forming these homo-oligomeric bundles [1].

This clan contains 11 families and the total number of domains in the clan is 17115. The clan was built by P Coggill.

Literature references

  1. Kim S, Jeon TJ, Oberai A, Yang D, Schmidt JJ, Bowie JU;, Proc Natl Acad Sci U S A. 2005;102:14278-14283.: Transmembrane glycine zippers: physiological and pathological roles in membrane proteins. PUBMED:16179394 EPMC:16179394


This clan contains the following 11 member families:

17kDa_Anti_2 DUF1269 DUF3482 DUF456 DUF5061 DUF883_C Gly-zipper_Omp Gly-zipper_OmpA Gly-zipper_YMGG Rick_17kDa_Anti Romo1

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Rick_17kDa_Anti (PF05433) 4774 (27.9%) View
Gly-zipper_Omp (PF13488) 3115 (18.2%) View
DUF456 (PF04306) 2253 (13.2%) View
DUF883_C (PF19029) 1608 (9.4%) View
Romo1 (PF10247) 1427 (8.3%) View
Gly-zipper_YMGG (PF13441) 1308 (7.6%) View
DUF1269 (PF06897) 1058 (6.2%) View
17kDa_Anti_2 (PF16998) 718 (4.2%) View
DUF3482 (PF11981) 492 (2.9%) View
Gly-zipper_OmpA (PF13436) 299 (1.7%) View
DUF5061 (PF16587) 63 (0.4%) View
Total: 11 Total: 17115 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...