Powering down the Pfam website
On October 5th, we began redirecting traffic from Pfam (pfam.xfam.org) to InterPro (www.ebi.ac.uk/interpro). The Pfam website will remain available at pfam-legacy.xfam.org until January 2023, when it will be decommissioned. You can read more about the sunset period in our blog post.

Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
654  structures 8261  species 0  interactions 128782  sequences 536  architectures

Clan: Glyoxalase (CL0104)


VOC superfamily Add an annotation

This clan contains the VOC metalloenzyme superfamily [1]. The known types of reactions that are catalysed include isomerizations (glyoxalase I), epimerizations (methylmalonyl-CoA epimerase), oxidative cleavage of C-C bonds (extradiol dioxygenase), and nucleophilic substitutions (fosfomycin resistance proteins) [1].

This clan contains 14 families and the total number of domains in the clan is 128782. The clan was built by A Bateman.

Literature references

  1. Armstrong RN; , Biochemistry 2000;39:13625-13632.: Mechanistic diversity in a metalloenzyme superfamily. PUBMED:11076500 EPMC:11076500


This clan contains the following 14 member families:

3-dmu-9_3-mt CppA_C CppA_N DUF1338 Glyoxalase Glyoxalase_2 Glyoxalase_3 Glyoxalase_4 Glyoxalase_5 Glyoxalase_6 Glyoxalase_7 Glyoxalase_8 TxDE YecM

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Glyoxalase (PF00903) 78703 (61.1%) View
Glyoxalase_6 (PF18029) 21645 (16.8%) View
Glyoxalase_4 (PF13669) 9656 (7.5%) View
3-dmu-9_3-mt (PF06983) 7691 (6.0%) View
Glyoxalase_5 (PF14696) 3015 (2.3%) View
Glyoxalase_3 (PF13468) 3008 (2.3%) View
DUF1338 (PF07063) 1939 (1.5%) View
Glyoxalase_2 (PF12681) 1357 (1.1%) View
Glyoxalase_7 (PF19581) 791 (0.6%) View
Glyoxalase_8 (PF20066) 468 (0.4%) View
YecM (PF06185) 293 (0.2%) View
CppA_C (PF14507) 84 (0.1%) View
TxDE (PF18711) 68 (0.1%) View
CppA_N (PF14506) 64 (0.0%) View
Total: 14 Total: 128782 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...