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177  structures 8208  species 0  interactions 57542  sequences 415  architectures

Clan: HMA (CL0704)


HMA domain superfamily Add an annotation

This superfamily includes families that are involved in heavy metals transport or in detoxification pathways. The Heavy-Metal -Associated (HMA) domain contains two conserved Cys and a common structure comprising a four-stranded antiparallel beta-sheet and two alpha-helices packed in an alpha-beta sandwich fold.

This clan contains 2 families and the total number of domains in the clan is 57542. The clan was built by S Chuguransky and A Bateman.

Literature references

  1. J Gitschier, B Moffat, D Reilly, W I Wood, W J Fairbrother, Nat Struct Biol. 1998 Jan;5(1):47-54. doi: 10.1038/nsb0198-47.: Solution structure of the fourth metal-binding domain from the Menkes copper-transporting ATPase PUBMED:9437429 EPMC:9437429
  2. Rosenzweig AC, Huffman DL, Hou MY, Wernimont AK, Pufahl RA, O'Halloran TV; , Structure Fold Des 1999;7:605-617.: Crystal structure of the Atx1 metallochaperone protein at 1.02 A resolution. PUBMED:10404590 EPMC:10404590


This clan contains the following 2 member families:


External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
HMA (PF00403) 56698 (98.5%) View
HMA_2 (PF19991) 844 (1.5%) View
Total: 2 Total: 57542 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...