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225  structures 8043  species 0  interactions 41265  sequences 974  architectures

Clan: HeH (CL0306)


LEM/SAP HeH motif Add an annotation

This superfamily includes protein domains with the helix-extended loop-helix (HeH) structure.

This clan contains 14 families and the total number of domains in the clan is 41265. The clan was built by A Bateman.

Literature references

  1. Okubo S, Hara F, Tsuchida Y, Shimotakahara S, Suzuki S, Hatanaka H, Yokoyama S, Tanaka H, Yasuda H, Shindo H; , J Biol Chem. 2004;279:31455-31461.: NMR structure of the N-terminal domain of SUMO ligase PIAS1 and its interaction with tumor suppressor p53 and A/T-rich DNA oligomers. PUBMED:15133049 EPMC:15133049


This clan contains the following 14 member families:

ARMET_C BTHB Endonuc-dimeris FANC_SAP HeH LEM LETM1_RBD Lsr2 PADR1 PRP4 Rho_N SAP SAP_new25 Thymopoietin

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
SAP (PF02037) 13967 (33.8%) View
Rho_N (PF07498) 8859 (21.5%) View
LETM1_RBD (PF07766) 4417 (10.7%) View
PRP4 (PF08799) 3296 (8.0%) View
Lsr2 (PF11774) 2890 (7.0%) View
LEM (PF03020) 2800 (6.8%) View
PADR1 (PF08063) 1191 (2.9%) View
HeH (PF12949) 865 (2.1%) View
Thymopoietin (PF08198) 794 (1.9%) View
ARMET_C (PF10208) 770 (1.9%) View
BTHB (PF18410) 713 (1.7%) View
SAP_new25 (PF18953) 366 (0.9%) View
FANC_SAP (PF18081) 238 (0.6%) View
Endonuc-dimeris (PF09124) 99 (0.2%) View
Total: 14 Total: 41265 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...