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231  structures 3946  species 0  interactions 10025  sequences 535  architectures

Clan: Homing_endonuc (CL0324)


Homing endonuclease-like superfamily Add an annotation

This superfamily includes a variety of LAGLIDADG-like homing endonuclease like families.

This clan contains 7 families and the total number of domains in the clan is 10025. The clan was built by A Bateman.

Literature references

  1. Stoddard BL; , Q Rev Biophys. 2005;38:49-95.: Homing endonuclease structure and function. PUBMED:16336743 EPMC:16336743


This clan contains the following 7 member families:


External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
LAGLIDADG_WhiA (PF14527) 3357 (33.5%) View
WhiA_N (PF10298) 3014 (30.1%) View
LAGLIDADG_3 (PF14528) 2136 (21.3%) View
LAGLIDADG_1 (PF00961) 825 (8.2%) View
LAGLIDADG_2 (PF03161) 479 (4.8%) View
Hom_end (PF05204) 212 (2.1%) View
Endonuc_subdom (PF09062) 2 (0.0%) View
Total: 7 Total: 10025 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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