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3756  structures 8626  species 0  interactions 230895  sequences 3081  architectures

Clan: Ion_channel (CL0030)


Ion channel (VIC) superfamily Add an annotation

This superfamily contains a diverse range of ion channels that share a pair of transmembrane helices in common. This clan is classified as the VIC (Voltage-gated Ion Channel) superfamily in TCDB.

This clan contains 8 families and the total number of domains in the clan is 230895. The clan was built by A Bateman.


This clan contains the following 8 member families:

Ion_trans Ion_trans_2 IRK KdpA Lig_chan PKD_channel Polycystin_dom TrkH

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Ion_trans (PF00520) 139658 (60.5%) View
Ion_trans_2 (PF07885) 38525 (16.7%) View
Lig_chan (PF00060) 21543 (9.3%) View
TrkH (PF02386) 12573 (5.4%) View
IRK (PF01007) 6400 (2.8%) View
PKD_channel (PF08016) 5617 (2.4%) View
Polycystin_dom (PF20519) 3305 (1.4%) View
KdpA (PF03814) 3274 (1.4%) View
Total: 8 Total: 230895 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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