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67  structures 1450  species 0  interactions 16183  sequences 225  architectures

Clan: KA1-like (CL0573)


Kinase associated domain 1-like Add an annotation

This superfamily is characterised by small adenylate-sensing domains at the C-terminus of molecules such as AMP-Activated Protein Kinases an SNF1-like protein kinases [1].

This clan contains 4 families and the total number of domains in the clan is 16183. The clan was built by P Coggill.

Literature references

  1. Moravcevic K, Mendrola JM, Schmitz KR, Wang YH, Slochower D, Janmey PA, Lemmon MA;, Cell. 2010;143:966-977.: Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids. PUBMED:21145462 EPMC:21145462


This clan contains the following 4 member families:

AdenylateSensor KA1 NAF NAM-associated

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
KA1 (PF02149) 6617 (40.9%) View
NAF (PF03822) 5514 (34.1%) View
NAM-associated (PF14303) 2160 (13.3%) View
AdenylateSensor (PF16579) 1892 (11.7%) View
Total: 4 Total: 16183 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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