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6  structures 8903  species 0  interactions 133318  sequences 352  architectures

Clan: LysE (CL0292)


LysE transporter superfamily Add an annotation

This clan includes a diverse range of transporter families [1].

This clan contains 19 families and the total number of domains in the clan is 133318. The clan was built by A Bateman.

Literature references

  1. Vrljic M, Garg J, Bellmann A, Wachi S, Freudl R, Malecki MJ, Sahm H, Kozina VJ, Eggeling L, Saier MH Jr, Eggeling L, Saier MH Jr; , J Mol Microbiol Biotechnol. 1999;1:327-336.: The LysE superfamily: topology of the lysine exporter LysE of Corynebacterium glutamicum, a paradyme for a novel superfamily of transmembrane solute translocators. PUBMED:10943564 EPMC:10943564


This clan contains the following 19 member families:

BacA Cad Colicin_V DsbD DsbD_2 DUF475 DUF6044 FTR1 HupE_UreJ HupE_UreJ_2 LysE MarC Mntp NicO OFeT_1 SfLAP TauE TerC UPF0016

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
TauE (PF01925) 32027 (24.0%) View
LysE (PF01810) 23774 (17.8%) View
TerC (PF03741) 11049 (8.3%) View
DsbD (PF02683) 10963 (8.2%) View
UPF0016 (PF01169) 10303 (7.7%) View
BacA (PF02673) 8870 (6.7%) View
Colicin_V (PF02674) 6920 (5.2%) View
MarC (PF01914) 6140 (4.6%) View
FTR1 (PF03239) 4701 (3.5%) View
Mntp (PF02659) 3906 (2.9%) View
NicO (PF03824) 3631 (2.7%) View
DsbD_2 (PF13386) 3436 (2.6%) View
HupE_UreJ_2 (PF13795) 2451 (1.8%) View
HupE_UreJ (PF04955) 1386 (1.0%) View
SfLAP (PF11139) 1237 (0.9%) View
DUF475 (PF04332) 1175 (0.9%) View
Cad (PF03596) 1012 (0.8%) View
DUF6044 (PF19510) 253 (0.2%) View
OFeT_1 (PF16955) 84 (0.1%) View
Total: 19 Total: 133318 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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