Summary
Methyl-coenzyme M reductase subunit superfamily
Methyl-coenzyme M reductase (MCR) is the enzyme responsible for microbial formation of methane. It is a hexamer composed of 2 alpha (Pfam:PF02745), 2 beta (Pfam:PF02241), and 2 gamma (Pfam:PF02240) subunits with two identical nickel porphinoid active sites. The N-terminal domain has a ferredoxin-like fold.
This clan contains 3 families and the total number of domains in the clan is 256. The clan was built by A Bateman.
Members
This clan contains the following 3 member families:
MCR_alpha_N MCR_beta_N MCR_gammaExternal database links
SCOP: | 55088 |
Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
Pfam family | Num. domains | Alignment |
---|---|---|
MCR_beta_N (PF02783) | 86 (33.6%) | View |
MCR_alpha_N (PF02745) | 86 (33.6%) | View |
MCR_gamma (PF02240) | 84 (32.8%) | View |
Total: 3 | Total: 256 | Clan alignment |
Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.
Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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