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33  structures 8219  species 0  interactions 154843  sequences 209  architectures

Clan: Membrane_trans (CL0142)


Membrane and transport protein Add an annotation

This clan contains membrane proteins involved in the transport of molecules including amino acids sugars and signalling molecules. It also includes integral membrane cell cycle proteins and some putative ammonia monooxygenases.

This clan contains 7 families and the total number of domains in the clan is 154843. The clan was built by J Mistry.

Literature references

  1. Staudenmaier H, Van Hove B, Yaraghi Z, Braun V; , J Bacteriol 1989;171:2626-2633.: Nucleotide sequences of the fecBCDE genes and locations of the proteins suggest a periplasmic-binding-protein-dependent transport mechanism for iron(III) dicitrate in Escherichia coli. PUBMED:2651410 EPMC:2651410
  2. Schmitt L, Tampe R; , Curr Opin Struct Biol 2002;12:754-760.: Structure and mechanism of ABC transporters. PUBMED:12504680 EPMC:12504680
  3. Hogg RW, Voelker C, Von Carlowitz I; , Mol Gen Genet 1991;229:453-459.: Nucleotide sequence and analysis of the mgl operon of Escherichia coli K12. PUBMED:1719366 EPMC:1719366
  4. Ikeda M, Sato T, Wachi M, Jung HK, Ishino F, Kobayashi Y, Matsuhashi M; , J Bacteriol 1989;171:6375-6378.: Structural similarity among Escherichia coli FtsW and RodA proteins and Bacillus subtilis SpoVE protein, which function in cell division, cell elongation, and spore formation, respectively. PUBMED:2509435 EPMC:2509435


This clan contains the following 7 member families:

ABC-3 AbrB BPD_transp_2 DUF1275 FecCD FTSW_RODA_SPOVE Pam17

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
BPD_transp_2 (PF02653) 87777 (56.7%) View
FecCD (PF01032) 26995 (17.4%) View
FTSW_RODA_SPOVE (PF01098) 19445 (12.6%) View
ABC-3 (PF00950) 11921 (7.7%) View
DUF1275 (PF06912) 5262 (3.4%) View
AbrB (PF05145) 2672 (1.7%) View
Pam17 (PF08566) 771 (0.5%) View
Total: 7 Total: 154843 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...