Summary
NAD-kinase beta sandwich domain superfamily
This superfamily includes families that are related to the C-terminal beta sandwich domain of NAD kinase. It includes the YegS C-terminal domain, the accessory domains from Diacylglycerol kinase and the ceramide kinase C-terminal domain.
This clan contains 4 families and the total number of domains in the clan is 35720. The clan was built by A Bateman.
Literature references
- Bakali HM, Herman MD, Johnson KA, Kelly AA, Wieslander A, Hallberg BM, Nordlund P; , J Biol Chem. 2007;282:19644-19652.: Crystal structure of YegS, a homologue to the mammalian diacylglycerol kinases, reveals a novel regulatory metal binding site. PUBMED:17351295 EPMC:17351295
Members
This clan contains the following 4 member families:
CERK_C DAGK_acc NAD_kinase_C YegS_CDomain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
Pfam family | Num. domains | Alignment |
---|---|---|
NAD_kinase_C (PF20143) | 13354 (37.4%) | View |
YegS_C (PF19279) | 10970 (30.7%) | View |
DAGK_acc (PF00609) | 10032 (28.1%) | View |
CERK_C (PF19280) | 1364 (3.8%) | View |
Total: 4 | Total: 35720 | Clan alignment |
Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.
Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
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HideThis tree shows the occurrence of the domains in this clan across different species. More...
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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