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1316  structures 8125  species 0  interactions 101059  sequences 1139  architectures

Clan: NTF2 (CL0051)


NTF2-like superfamily Add an annotation

This superfamily contains a variety of enzymes such as Scytalone dehydratase, Delta-5-3-ketosteroid isomerase, Limonene-1,2-epoxide hydrolase among others. The family also includes presumed non-enzymatic homologues such as NTF2.

This clan contains 46 families and the total number of domains in the clan is 101059. The clan was built by A Bateman.

Literature references

  1. Nagata Y, Mori K, Takagi M, Murzin AG, Damborsky J; , Proteins 2001;45:471-477.: Identification of protein fold and catalytic residues of gamma-hexachlorocyclohexane dehydrochlorinase LinA. PUBMED:11746694 EPMC:11746694


This clan contains the following 46 member families:

ARC6-like_IMS CaMKII_AD Coa1 DUF1348 DUF2358 DUF3225 DUF3804 DUF3828 DUF3887 DUF4019 DUF4348 DUF4440 DUF4467 DUF4518 DUF4783 DUF4829 DUF4864 DUF4878 DUF4904 DUF5104 DUF5105 DUF6715 Endopep_inhib LEH Lumazine_bd_2 MBA1 MecA_N MlaC Mtr2 NTF2 ORF_12_N PHZA_PHZB Ring_hydroxyl_B Scytalone_dh SnoaL SnoaL_2 SnoaL_3 SnoaL_4 SnoaL_5 T4BSS_DotI_IcmL TIM21 Tim44 TpcC UPF0225 VirB8 WI12

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
SnoaL_2 (PF12680) 22205 (22.0%) View
SnoaL_4 (PF13577) 9048 (9.0%) View
NTF2 (PF02136) 9024 (8.9%) View
DUF4440 (PF14534) 7734 (7.7%) View
CaMKII_AD (PF08332) 6496 (6.4%) View
SnoaL (PF07366) 6102 (6.0%) View
Tim44 (PF04280) 5655 (5.6%) View
SnoaL_3 (PF13474) 4713 (4.7%) View
UPF0225 (PF17775) 3051 (3.0%) View
MlaC (PF05494) 2850 (2.8%) View
DUF1348 (PF07080) 2283 (2.3%) View
DUF2358 (PF10184) 2204 (2.2%) View
Ring_hydroxyl_B (PF00866) 2119 (2.1%) View
VirB8 (PF04335) 2083 (2.1%) View
MecA_N (PF05223) 1823 (1.8%) View
Lumazine_bd_2 (PF12893) 1629 (1.6%) View
Coa1 (PF08695) 1597 (1.6%) View
TIM21 (PF08294) 1582 (1.6%) View
DUF3225 (PF11533) 689 (0.7%) View
ARC6-like_IMS (PF13355) 682 (0.7%) View
DUF4864 (PF16156) 624 (0.6%) View
WI12 (PF07107) 604 (0.6%) View
DUF3887 (PF13026) 577 (0.6%) View
Scytalone_dh (PF02982) 558 (0.6%) View
Pfam family Num. domains Alignment
TpcC (PF12642) 523 (0.5%) View
SnoaL_5 (PF20409) 508 (0.5%) View
LEH (PF07858) 497 (0.5%) View
DUF4518 (PF15008) 410 (0.4%) View
DUF4783 (PF16022) 384 (0.4%) View
DUF3828 (PF12883) 368 (0.4%) View
DUF4019 (PF13211) 363 (0.4%) View
DUF4878 (PF12870) 315 (0.3%) View
MBA1 (PF07961) 314 (0.3%) View
T4BSS_DotI_IcmL (PF11393) 232 (0.2%) View
ORF_12_N (PF18042) 158 (0.2%) View
DUF4348 (PF14254) 150 (0.1%) View
Endopep_inhib (PF16800) 140 (0.1%) View
Mtr2 (PF10429) 132 (0.1%) View
DUF5105 (PF17118) 129 (0.1%) View
DUF4829 (PF16111) 123 (0.1%) View
DUF5104 (PF17117) 122 (0.1%) View
PHZA_PHZB (PF03284) 116 (0.1%) View
DUF6715 (PF20462) 112 (0.1%) View
DUF4467 (PF14729) 15 (0.0%) View
DUF3804 (PF12707) 13 (0.0%) View
DUF4904 (PF16247) 3 (0.0%) View
Total: 46 Total: 101059
No alignment ℹ

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...