Summary
NTF2-like superfamily
This superfamily contains a variety of enzymes such as Scytalone dehydratase, Delta-5-3-ketosteroid isomerase, Limonene-1,2-epoxide hydrolase among others. The family also includes presumed non-enzymatic homologues such as NTF2.
This clan contains 46 families and the total number of domains in the clan is 101059. The clan was built by A Bateman.
Literature references
- Nagata Y, Mori K, Takagi M, Murzin AG, Damborsky J; , Proteins 2001;45:471-477.: Identification of protein fold and catalytic residues of gamma-hexachlorocyclohexane dehydrochlorinase LinA. PUBMED:11746694 EPMC:11746694
Members
This clan contains the following 46 member families:
ARC6-like_IMS CaMKII_AD Coa1 DUF1348 DUF2358 DUF3225 DUF3804 DUF3828 DUF3887 DUF4019 DUF4348 DUF4440 DUF4467 DUF4518 DUF4783 DUF4829 DUF4864 DUF4878 DUF4904 DUF5104 DUF5105 DUF6715 Endopep_inhib LEH Lumazine_bd_2 MBA1 MecA_N MlaC Mtr2 NTF2 ORF_12_N PHZA_PHZB Ring_hydroxyl_B Scytalone_dh SnoaL SnoaL_2 SnoaL_3 SnoaL_4 SnoaL_5 T4BSS_DotI_IcmL TIM21 Tim44 TpcC UPF0225 VirB8 WI12External database links
CATH: | 3.10.30.90 |
SCOP: | 54427 |
Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
Pfam family | Num. domains | Alignment |
---|---|---|
SnoaL_2 (PF12680) | 22205 (22.0%) | View |
SnoaL_4 (PF13577) | 9048 (9.0%) | View |
NTF2 (PF02136) | 9024 (8.9%) | View |
DUF4440 (PF14534) | 7734 (7.7%) | View |
CaMKII_AD (PF08332) | 6496 (6.4%) | View |
SnoaL (PF07366) | 6102 (6.0%) | View |
Tim44 (PF04280) | 5655 (5.6%) | View |
SnoaL_3 (PF13474) | 4713 (4.7%) | View |
UPF0225 (PF17775) | 3051 (3.0%) | View |
MlaC (PF05494) | 2850 (2.8%) | View |
DUF1348 (PF07080) | 2283 (2.3%) | View |
DUF2358 (PF10184) | 2204 (2.2%) | View |
Ring_hydroxyl_B (PF00866) | 2119 (2.1%) | View |
VirB8 (PF04335) | 2083 (2.1%) | View |
MecA_N (PF05223) | 1823 (1.8%) | View |
Lumazine_bd_2 (PF12893) | 1629 (1.6%) | View |
Coa1 (PF08695) | 1597 (1.6%) | View |
TIM21 (PF08294) | 1582 (1.6%) | View |
DUF3225 (PF11533) | 689 (0.7%) | View |
ARC6-like_IMS (PF13355) | 682 (0.7%) | View |
DUF4864 (PF16156) | 624 (0.6%) | View |
WI12 (PF07107) | 604 (0.6%) | View |
DUF3887 (PF13026) | 577 (0.6%) | View |
Scytalone_dh (PF02982) | 558 (0.6%) | View |
continued |
Pfam family | Num. domains | Alignment |
---|---|---|
TpcC (PF12642) | 523 (0.5%) | View |
SnoaL_5 (PF20409) | 508 (0.5%) | View |
LEH (PF07858) | 497 (0.5%) | View |
DUF4518 (PF15008) | 410 (0.4%) | View |
DUF4783 (PF16022) | 384 (0.4%) | View |
DUF3828 (PF12883) | 368 (0.4%) | View |
DUF4019 (PF13211) | 363 (0.4%) | View |
DUF4878 (PF12870) | 315 (0.3%) | View |
MBA1 (PF07961) | 314 (0.3%) | View |
T4BSS_DotI_IcmL (PF11393) | 232 (0.2%) | View |
ORF_12_N (PF18042) | 158 (0.2%) | View |
DUF4348 (PF14254) | 150 (0.1%) | View |
Endopep_inhib (PF16800) | 140 (0.1%) | View |
Mtr2 (PF10429) | 132 (0.1%) | View |
DUF5105 (PF17118) | 129 (0.1%) | View |
DUF4829 (PF16111) | 123 (0.1%) | View |
DUF5104 (PF17117) | 122 (0.1%) | View |
PHZA_PHZB (PF03284) | 116 (0.1%) | View |
DUF6715 (PF20462) | 112 (0.1%) | View |
DUF4467 (PF14729) | 15 (0.0%) | View |
DUF3804 (PF12707) | 13 (0.0%) | View |
DUF4904 (PF16247) | 3 (0.0%) | View |
Total: 46 | Total: 101059 |
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Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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