Nckap1/CYFIP 1/2 superfamily

This clan includes components of the WASH and WAVE complexes which are structurally similar and regulate actin cytoskeletal dynamics through the control of Arp2-3 complex-mediated actin assembly [1,2,3]. WAVE is found in all eukaryotic kingdoms and plays a crucial role in many cellular processes including adhesion, migration, division and fusion [1]. In animals, WAVE proteins are important for a wide range of processes such as embryogenesis, neuron morphogenesis and plasticity, immune cell activation and chemotaxis, and cancer invasion and metastasis [1]. WASH, conserved from simple eukaryotes to human, localizes to early endosomal subdomains and regulates endocytic vesicle scission in an Arp2-3-dependent manner [3]. Including in this clan are Cytoplasmic FMR1-interacting proteins CYFIP1 and CYFIP2, Nck-associated protein 1 (Nckap1) from WAVE complex and WASH complex subunit 7 (KIAA1033).

This clan contains 3 families and the total number of domains in the clan is 5917. The clan was built by S Chuguransky.

Literature references

1. Chen B, Brinkmann K, Chen Z, Pak CW, Liao Y, Shi S, Henry L, Grishin NV, Bogdan S, Rosen MK;, Cell. 2014;156:195-207.: The WAVE regulatory complex links diverse receptors to the actin cytoskeleton. PUBMED:24439376 EPMC:24439376
2. Chen Z, Borek D, Padrick SB, Gomez TS, Metlagel Z, Ismail AM, Umetani J, Billadeau DD, Otwinowski Z, Rosen MK;, Nature. 2010;468:533-538.: Structure and control of the actin regulatory WAVE complex. PUBMED:21107423 EPMC:21107423
3. Jia D, Gomez TS, Metlagel Z, Umetani J, Otwinowski Z, Rosen MK, Billadeau DD;, Proc Natl Acad Sci U S A. 2010;107:10442-10447.: WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes. PUBMED:20498093 EPMC:20498093

Members

This clan contains the following 3 member families:

Below is a listing of the unique domain organisations or architectures from this clan. More...

The table below shows the number of occurrences of each domain throughout the sequence database. More...

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This diagram shows the relationships between members of this clan. More...

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.