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26  structures 1411  species 0  interactions 4820  sequences 83  architectures

Clan: Nucleoporin_A (CL0585)


Nucleoporin superfamily Add an annotation

This is a superfamily of nucleoporins. Nucleoporins are all-beta structures that form part of the nuclear-pore complex.

This clan contains 3 families and the total number of domains in the clan is 4820. The clan was built by P Coggill.

Literature references

  1. Berke IC, Boehmer T, Blobel G, Schwartz TU; , J Cell Biol. 2004;167:591-597.: Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex. PUBMED:15557116 EPMC:15557116


This clan contains the following 3 member families:

Nup188 Nup188_C Nup192

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Nup192 (PF11894) 2469 (51.2%) View
Nup188 (PF10487) 1771 (36.7%) View
Nup188_C (PF18378) 580 (12.0%) View
Total: 3 Total: 4820 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...