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457  structures 2753  species 0  interactions 77812  sequences 1042  architectures

Clan: PF (CL0431)


Profilin-like superfamily Add an annotation

The families here all show the Profilin-like fold, and represent both the Profilin (actin-binding protein) (55770) and the Roadblock/LC7 domain-type (103196) superfamilies.

This clan contains 21 families and the total number of domains in the clan is 77812. The clan was built by A Bateman.


This clan contains the following 21 member families:

Clat_adaptor_s FNIP_N Fuz_longin_1 Fuz_longin_2 Fuz_longin_3 Intu_longin_1 Intu_longin_2 Intu_longin_3 LAMTOR5 Longin Longin_2 MAPKK1_Int Nyv1_longin Profilin Robl_LC7 Sedlin_N SLM4 SRP-alpha_N SRX Sybindin uDENN

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Clat_adaptor_s (PF01217) 17353 (22.3%) View
uDENN (PF03456) 12794 (16.4%) View
Robl_LC7 (PF03259) 9334 (12.0%) View
Longin (PF13774) 8032 (10.3%) View
Profilin (PF00235) 3901 (5.0%) View
Sedlin_N (PF04628) 3584 (4.6%) View
Sybindin (PF04099) 3476 (4.5%) View
Fuz_longin_1 (PF19036) 3142 (4.0%) View
Fuz_longin_2 (PF19037) 3081 (4.0%) View
Fuz_longin_3 (PF19038) 2853 (3.7%) View
Intu_longin_1 (PF19031) 2665 (3.4%) View
Pfam family Num. domains Alignment
SRP-alpha_N (PF04086) 1876 (2.4%) View
FNIP_N (PF14636) 1548 (2.0%) View
Intu_longin_3 (PF19033) 1517 (1.9%) View
Intu_longin_2 (PF19032) 1195 (1.5%) View
MAPKK1_Int (PF08923) 659 (0.8%) View
LAMTOR5 (PF16672) 624 (0.8%) View
Longin_2 (PF18639) 68 (0.1%) View
SLM4 (PF16818) 56 (0.1%) View
SRX (PF09201) 28 (0.0%) View
Nyv1_longin (PF09426) 26 (0.0%) View
Total: 21 Total: 77812 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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