Summary
PIN domain superfamily
This superfamily contains a variety of nuclease enzymes, including PIN domains and the FLAP exonucleases.
This clan contains 27 families and the total number of domains in the clan is 91630. The clan was built by A Bateman.
Literature references
- Matelska D, Steczkiewicz K, Ginalski K;, Nucleic Acids Res. 2017;45:6995-7020.: Comprehensive classification of the PIN domain-like superfamily. PUBMED:28575517 EPMC:28575517
- Glavan F, Behm-Ansmant I, Izaurralde E, Conti E; , EMBO J. 2006;25:5117-5125.: Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. PUBMED:17053788 EPMC:17053788
- Glavan F, Behm-Ansmant I, Izaurralde E, Conti E; , EMBO J. 2006;25:5117-5125.: Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. PUBMED:17053788 EPMC:17053788
- Anantharaman V, Aravind L; , RNA Biol. 2006; [Epub ahead of print]: The NYN Domains: Novel Predicted RNAses with a PIN Domain-Like Fold. PUBMED:17114934 EPMC:17114934
Members
This clan contains the following 27 member families:
5_3_exonuc_N DUF1308 DUF188 DUF4411 DUF5615 DUF5616 Fcf1 Mut7-C NYN NYN_YacP PIN PIN7 PIN_10 PIN_11 PIN_12 PIN_2 PIN_3 PIN_4 PIN_5 PIN_6 PIN_8 PIN_9 PRORP RNase_Zc3h12a RNase_Zc3h12a_2 XPG_N XRN_NExternal database links
| SCOP: | 88723 |
Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
| Pfam family | Num. domains | Alignment |
|---|---|---|
| PIN (PF01850) | 19626 (21.4%) | View |
| 5_3_exonuc_N (PF02739) | 11311 (12.3%) | View |
| NYN (PF01936) | 10788 (11.8%) | View |
| XPG_N (PF00752) | 8571 (9.4%) | View |
| PIN_4 (PF13638) | 8559 (9.3%) | View |
| XRN_N (PF03159) | 5007 (5.5%) | View |
| PIN_3 (PF13470) | 3718 (4.1%) | View |
| Fcf1 (PF04900) | 3610 (3.9%) | View |
| DUF188 (PF02639) | 3286 (3.6%) | View |
| RNase_Zc3h12a (PF11977) | 2991 (3.3%) | View |
| NYN_YacP (PF05991) | 2899 (3.2%) | View |
| Mut7-C (PF01927) | 2091 (2.3%) | View |
| PIN_6 (PF17146) | 1960 (2.1%) | View |
| DUF5615 (PF18480) | 1767 (1.9%) | View |
| continued | ||
| Pfam family | Num. domains | Alignment |
|---|---|---|
| PRORP (PF16953) | 1431 (1.6%) | View |
| DUF1308 (PF07000) | 1056 (1.2%) | View |
| DUF4411 (PF14367) | 432 (0.5%) | View |
| PIN_12 (PF16289) | 398 (0.4%) | View |
| PIN_11 (PF18479) | 330 (0.4%) | View |
| PIN_10 (PF18478) | 315 (0.3%) | View |
| PIN7 (PF18475) | 289 (0.3%) | View |
| PIN_9 (PF18477) | 283 (0.3%) | View |
| PIN_8 (PF18476) | 271 (0.3%) | View |
| PIN_2 (PF10130) | 242 (0.3%) | View |
| DUF5616 (PF18481) | 239 (0.3%) | View |
| PIN_5 (PF08745) | 126 (0.1%) | View |
| RNase_Zc3h12a_2 (PF14626) | 34 (0.0%) | View |
| Total: 27 | Total: 91630 | Clan alignment |
Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.
Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
Tree controls
HideThis tree shows the occurrence of the domains in this clan across different species. More...
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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