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731  structures 1624  species 0  interactions 166797  sequences 3504  architectures

Clan: POZ (CL0033)


POZ domain superfamily Add an annotation

The POZ domain is found in a variety of transcription factors. POZ domains are also found in the tetramerisation domain of voltage gated K+ channels. In general these domains mediate homo-oligomerisation.

This clan contains 6 families and the total number of domains in the clan is 166797. The clan was built by A Bateman.

Literature references

  1. Zollman S, Godt D, Prive GG, Couderc JL, Laski FA; , Proc Natl Acad Sci U S A 1994;91:10717-10721.: The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila. PUBMED:7938017 EPMC:7938017
  2. Bardwell VJ, Treisman R; , Genes Dev 1994;8:1664-1677.: The POZ domain: a conserved protein-protein interaction motif. PUBMED:7958847 EPMC:7958847


This clan contains the following 6 member families:


External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
BTB (PF00651) 103339 (62.0%) View
BACK (PF07707) 31766 (19.0%) View
BTB_2 (PF02214) 23172 (13.9%) View
Skp1_POZ (PF03931) 6678 (4.0%) View
BTB_3 (PF16017) 1199 (0.7%) View
SANBR_BTB (PF11822) 643 (0.4%) View
Total: 6 Total: 166797 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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