Summary
POZ domain superfamily
The POZ domain is found in a variety of transcription factors. POZ domains are also found in the tetramerisation domain of voltage gated K+ channels. In general these domains mediate homo-oligomerisation.
This clan contains 6 families and the total number of domains in the clan is 166797. The clan was built by A Bateman.
Literature references
- Zollman S, Godt D, Prive GG, Couderc JL, Laski FA; , Proc Natl Acad Sci U S A 1994;91:10717-10721.: The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila. PUBMED:7938017 EPMC:7938017
- Bardwell VJ, Treisman R; , Genes Dev 1994;8:1664-1677.: The POZ domain: a conserved protein-protein interaction motif. PUBMED:7958847 EPMC:7958847
Members
This clan contains the following 6 member families:
BACK BTB BTB_2 BTB_3 SANBR_BTB Skp1_POZExternal database links
CATH: | 3.30.710.10 |
SCOP: | 54695 |
Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
Pfam family | Num. domains | Alignment |
---|---|---|
BTB (PF00651) | 103339 (62.0%) | View |
BACK (PF07707) | 31766 (19.0%) | View |
BTB_2 (PF02214) | 23172 (13.9%) | View |
Skp1_POZ (PF03931) | 6678 (4.0%) | View |
BTB_3 (PF16017) | 1199 (0.7%) | View |
SANBR_BTB (PF11822) | 643 (0.4%) | View |
Total: 6 | Total: 166797 | Clan alignment |
Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.
Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
Tree controls
HideThis tree shows the occurrence of the domains in this clan across different species. More...
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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