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3765  structures 5066  species 0  interactions 88518  sequences 2916  architectures

Clan: Peptidase_AA (CL0129)


Peptidase clan AA Add an annotation

This clan contains aspartic peptidases, including the pepsins and retropepsins. These enzymes contains a catalytic dyad composed of two aspartates. In the retropepsins one is provided by each copy of a homodimeric protein, whereas in the pepsin-like peptidases these aspartates come from a single protein composed of two duplicated domains.

This clan contains 14 families and the total number of domains in the clan is 88518. The clan was built by A Bateman.


This clan contains the following 14 member families:

Asp Asp_protease Asp_protease_2 DUF1758 gag-asp_proteas Peptidase_A2_2 Peptidase_A2B Peptidase_A3 RVP RVP_2 Spuma_A9PTase TAXi_C TAXi_N Zn_protease

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Asp (PF00026) 24251 (27.4%) View
TAXi_N (PF14543) 14436 (16.3%) View
TAXi_C (PF14541) 14177 (16.0%) View
RVP_2 (PF08284) 10295 (11.6%) View
Asp_protease_2 (PF13650) 8005 (9.0%) View
gag-asp_proteas (PF13975) 6741 (7.6%) View
DUF1758 (PF05585) 3036 (3.4%) View
Asp_protease (PF09668) 2711 (3.1%) View
Zn_protease (PF05618) 2510 (2.8%) View
RVP (PF00077) 2204 (2.5%) View
Peptidase_A2B (PF12384) 53 (0.1%) View
Peptidase_A3 (PF02160) 51 (0.1%) View
Spuma_A9PTase (PF03539) 37 (0.0%) View
Peptidase_A2_2 (PF12382) 11 (0.0%) View
Total: 14 Total: 88518 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...