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1488  structures 7733  species 0  interactions 181951  sequences 1154  architectures

Clan: Periplas_BP (CL0144)


Periplasmic binding protein like Add an annotation

This clan includes proteins involved in chemotaxis, membrane transport of sugars and allocrites, and the LacI family transcriptional regulators. It also includes some antigenic basic membrane lipoproteins.

This clan contains 11 families and the total number of domains in the clan is 181951. The clan was built by J Mistry.

Literature references

  1. Lewis M, Chang G, Horton NC, Kercher MA, Pace HC, Schumacher MA, Brennan RG, Lu P; , Science 1996;271:1247-1254.: Crystal structure of the lactose operon repressor and its complexes with DNA and inducer. PUBMED:8638105 EPMC:8638105
  2. Mowbray SL, Cole LB; , J Mol Biol 1992;225:155-175.: 1.7 A X-ray structure of the periplasmic ribose receptor from Escherichia coli. PUBMED:1583688 EPMC:1583688
  3. Roessler D, Hauser U, Wilske B; , J Clin Microbiol 1997;35:2752-2758.: Heterogeneity of BmpA (P39) among European isolates of Borrelia burgdorferi sensu lato and influence of interspecies variability on serodiagnosis. PUBMED:9350727 EPMC:9350727


This clan contains the following 11 member families:

ABC_sub_bind ANF_receptor Bmp DUF3798 LppC Peripla_BP_1 Peripla_BP_3 Peripla_BP_4 Peripla_BP_5 Peripla_BP_6 Peripla_BP_7

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Peripla_BP_3 (PF13377) 54862 (30.2%) View
ANF_receptor (PF01094) 42473 (23.3%) View
Peripla_BP_6 (PF13458) 30703 (16.9%) View
Peripla_BP_4 (PF13407) 29832 (16.4%) View
Bmp (PF02608) 8653 (4.8%) View
Peripla_BP_1 (PF00532) 6690 (3.7%) View
ABC_sub_bind (PF04392) 4102 (2.3%) View
Peripla_BP_5 (PF13433) 3076 (1.7%) View
LppC (PF04348) 1254 (0.7%) View
DUF3798 (PF12683) 213 (0.1%) View
Peripla_BP_7 (PF18610) 93 (0.1%) View
Total: 11 Total: 181951 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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