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1608  structures 9107  species 0  interactions 86447  sequences 354  architectures

Clan: SIS (CL0067)


SIS domain fold Add an annotation

This catalytic domain catalyses isomerisation reactions of a variety of sugars [1].

This clan contains 8 families and the total number of domains in the clan is 86447. The clan was built by A Bateman.

Literature references

  1. Bateman A; , Trends Biochem Sci 1999;24:94-95.: The SIS domain: a phosphosugar-binding domain. PUBMED:10203754 EPMC:10203754


This clan contains the following 8 member families:

bact-PGI_C DUF2529 HobA PGI Phosphatase Ribosomal_S2 SIS SIS_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
SIS (PF01380) 48666 (56.3%) View
Ribosomal_S2 (PF00318) 15891 (18.4%) View
PGI (PF00342) 12267 (14.2%) View
SIS_2 (PF13580) 7534 (8.7%) View
bact-PGI_C (PF10432) 1069 (1.2%) View
Phosphatase (PF15698) 695 (0.8%) View
DUF2529 (PF10740) 247 (0.3%) View
HobA (PF12163) 78 (0.1%) View
Total: 8 Total: 86447 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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