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0  structures 1330  species 0  interactions 2482  sequences 40  architectures

Clan: SLATT (CL0676)


SMODS and LOG-Smf/DprA-Associating Two TM Add an annotation

Members of the SLATT clan carry two transmembrane (TM) helices and are found to frequently link the SMODS and SLOG domains. Sequence analysis indicate the presence of a conserved core for the domain consisting of a pair of N-terminal TM helices and a largely helical C-terminal cytoplasmic region. The TM helices often contain family-specific polar residues that are likely to form an intramembrane aqueous channel that might facilitate transport of molecules across the membrane [1].

This clan contains 8 families and the total number of domains in the clan is 2482. The clan was built by S El-Gebali.

Literature references

  1. Burroughs AM, Zhang D, Schaffer DE, Iyer LM, Aravind L;, Nucleic Acids Res. 2015;43:10633-10654.: Comparative genomic analyses reveal a vast, novel network of nucleotide-centric systems in biological conflicts, immunity and signaling. PUBMED:26590262 EPMC:26590262


This clan contains the following 8 member families:


Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
SLATT_fungal (PF18142) 850 (34.2%) View
DUF4231 (PF14015) 466 (18.8%) View
SLATT_2 (PF18183) 364 (14.7%) View
SLATT_1 (PF18181) 329 (13.3%) View
SLATT_3 (PF18184) 214 (8.6%) View
SLATT_4 (PF18186) 122 (4.9%) View
SLATT_5 (PF18160) 108 (4.4%) View
SLATT_6 (PF18169) 29 (1.2%) View
Total: 8 Total: 2482 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...