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48  structures 8679  species 0  interactions 42372  sequences 303  architectures

Clan: SPFH (CL0433)


SPFH superfamily Add an annotation

This superfamily includes the SPFH family as well as the shoulder domain from the Major Vault Protein [1].

This clan contains 3 families and the total number of domains in the clan is 42372. The clan was built by A Bateman.

Literature references

  1. Tanaka H, Kato K, Yamashita E, Sumizawa T, Zhou Y, Yao M, Iwasaki K, Yoshimura M, Tsukihara T;, Science. 2009;323:384-388.: The structure of rat liver vault at 3.5 angstrom resolution. PUBMED:19150846 EPMC:19150846


This clan contains the following 3 member families:

Band_7 Band_7_1 MVP_shoulder

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Band_7 (PF01145) 39621 (93.5%) View
Band_7_1 (PF13421) 2085 (4.9%) View
MVP_shoulder (PF11978) 666 (1.6%) View
Total: 3 Total: 42372 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...