Summary
SPOC domain-like superfamily
The crystal structure of the SPOC domain [3] showed it has similarity with the beta barrel domain of the Ku proteins. These domains share a 7 stranded beta barrel. In the Ku proteins this domain interacts DNA, whereas the SPOC domain mediates protein binding.
This clan contains 4 families and the total number of domains in the clan is 13621. The clan was built by A Bateman.
Literature references
- Sanchez-Pulido L, Rojas AM, van Wely KH, Martinez-A C, Valencia A;, BMC Bioinformatics. 2004;5:91.: SPOC: a widely distributed domain associated with cancer, apoptosis and transcription. PUBMED:15239844 EPMC:15239844
- Mikami S, Kanaba T, Ito Y, Mishima M;, Biomol NMR Assign. 2013;7:267-270.: NMR assignments of SPOC domain of the human transcriptional corepressor SHARP in complex with a C-terminal SMRT peptide. PUBMED:22987228 EPMC:22987228
- Ariyoshi M, Schwabe JW; , Genes Dev 2003;17:1909-1920.: A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling. PUBMED:12897056 EPMC:12897056
Members
This clan contains the following 4 member families:
Ku Med25 Sld7_N SPOCExternal database links
SCOP: | 100939 |
Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
Pfam family | Num. domains | Alignment |
---|---|---|
Ku (PF02735) | 7775 (57.1%) | View |
SPOC (PF07744) | 4776 (35.1%) | View |
Med25 (PF11232) | 1027 (7.5%) | View |
Sld7_N (PF18636) | 43 (0.3%) | View |
Total: 4 | Total: 13621 | Clan alignment |
Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.
Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
Tree controls
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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