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142  structures 365  species 0  interactions 581  sequences 18  architectures

Clan: STING (CL0709)


STING domain superfamily Add an annotation

This clan includes families containing the STING sensor domain which recognises and binds nucleotides [1,2] to activate fused effector domains and trigger different signalling pathways, such as animal innate immune response pathways. It consists of transmembrane helices followed by a cytoplasmic ligand-binding and signalling domain [2].

This clan contains 2 families and the total number of domains in the clan is 581. The clan was built by S;0000-0002-0520-0736 Chuguransky.

Literature references

  1. Burroughs AM, Aravind L;, J Bacteriol. 2020; [Epub ahead of print]: Identification of Uncharacterized Components of Prokaryotic Immune Systems and Their Diverse Eukaryotic Reformulations. PUBMED:32868406 EPMC:32868406
  2. Shang G, Zhang C, Chen ZJ, Bai XC, Zhang X;, Nature. 2019;567:389-393.: Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP. PUBMED:30842659 EPMC:30842659


This clan contains the following 2 member families:

prok_STING TMEM173

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
TMEM173 (PF15009) 523 (90.0%) View
prok_STING (PF20300) 58 (10.0%) View
Total: 2 Total: 581 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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