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22  structures 3159  species 0  interactions 8712  sequences 126  architectures

Clan: SUKH (CL0526)


SUKH superfamily Add an annotation

SUKH superfamily unites a diverse group of proteins including Smi1/Knr4, PGs2, Fbxo3, Skip16, Syd, herpesviral US22, IRS1 and TRS1, and their bacterial homologs [1].

This clan contains 7 families and the total number of domains in the clan is 8712. The clan was built by D ZhangLM Iyer and L Aravind.

Literature references

  1. Zhang D, Iyer LM, Aravind L;, Nucleic Acids Res. 2011;39:4532-4552.: A novel immunity system for bacterial nucleic acid degrading toxins and its recruitment in various eukaryotic and DNA viral systems. PUBMED:21306995 EPMC:21306995


This clan contains the following 7 member families:


Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
SMI1_KNR4 (PF09346) 4195 (48.2%) View
SUKH_6 (PF14568) 1302 (14.9%) View
SUKH-4 (PF14435) 1104 (12.7%) View
SUKH-3 (PF14433) 656 (7.5%) View
US22 (PF02393) 613 (7.0%) View
SUKH_5 (PF14567) 482 (5.5%) View
Syd (PF07348) 360 (4.1%) View
Total: 7 Total: 8712 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...