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7  structures 5941  species 0  interactions 30469  sequences 365  architectures

Clan: Steroid_dh (CL0115)


Steroid oxidoreductase superfamily Add an annotation

This clan includes several enzymes, including steroid dehydrogenases and isoprenylcysteine carboxyl methyltransferase enzymes. These protein contain a varying number of transmembrane regions.

This clan contains 6 families and the total number of domains in the clan is 30469. The clan was built by A Bateman.


This clan contains the following 6 member families:

DUF1295 ERG4_ERG24 ICMT NnrU PEMT Steroid_dh

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PEMT (PF04191) 7608 (25.0%) View
Steroid_dh (PF02544) 6283 (20.6%) View
DUF1295 (PF06966) 4933 (16.2%) View
ICMT (PF04140) 4819 (15.8%) View
ERG4_ERG24 (PF01222) 4643 (15.2%) View
NnrU (PF07298) 2183 (7.2%) View
Total: 6 Total: 30469 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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