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23  structures 308  species 0  interactions 619  sequences 8  architectures

Clan: T3SS (CL0646)


Type III secretion system domain superfamily Add an annotation

This superfamily includes a range of proteins involved in regulation of secretion by type III secretion systems, such as HrpJ, TyeA and YopR.

This clan contains 4 families and the total number of domains in the clan is 619. The clan was built by A Bateman.


This clan contains the following 4 member families:

HrpJ T3SS_needle_reg TyeA UPF0058

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
UPF0058 (PF01893) 324 (52.3%) View
HrpJ (PF07201) 199 (32.1%) View
TyeA (PF09059) 87 (14.1%) View
T3SS_needle_reg (PF09025) 9 (1.5%) View
Total: 4 Total: 619 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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