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281  structures 6180  species 0  interactions 18297  sequences 181  architectures

Clan: TBP-like (CL0407)


TATA-binding protein like Add an annotation

TBP is a transcription factor whose DNA binding fold is composed of a curved antiparallel beta-sheet [1]. This fold is also found in the N terminal region of DNA repair glycosylases. The N terminal domain of DNA glycosylase has only a single copy of the fold, whereas TBP contains a duplication of this fold [2-3].

This clan contains 10 families and the total number of domains in the clan is 18297. The clan was built by J Mistry and RD Finn.

Literature references

  1. Nikolov DB, Hu SH, Lin J, Gasch A, Hoffmann A, Horikoshi M, Chua NH, Roeder RG, Burley SK; , Nature 1992;360:40-46.: Crystal structure of TFIID TATA-box binding protein. PUBMED:1436073 EPMC:1436073
  2. Fromme JC, Banerjee A, Verdine GL;, Curr Opin Struct Biol. 2004;14:43-49.: DNA glycosylase recognition and catalysis. PUBMED:15102448 EPMC:15102448
  3. Hollis T, Lau A, Ellenberger T;, Prog Nucleic Acid Res Mol Biol. 2001;68:305-314.: Crystallizing thoughts about DNA base excision repair. PUBMED:11554308 EPMC:11554308


This clan contains the following 10 member families:

AdoMet_dc AlkA_N DUF3378 DUF5611 OGG_N Phage_CRI Rep_trans Rol_Rep_N SpmSyn_N TBP

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
TBP (PF00352) 7937 (43.4%) View
AdoMet_dc (PF02675) 3225 (17.6%) View
OGG_N (PF07934) 2588 (14.1%) View
AlkA_N (PF06029) 2295 (12.5%) View
Rep_trans (PF02486) 595 (3.3%) View
DUF3378 (PF11858) 530 (2.9%) View
SpmSyn_N (PF17950) 425 (2.3%) View
Rol_Rep_N (PF18106) 340 (1.9%) View
Phage_CRI (PF05144) 191 (1.0%) View
DUF5611 (PF18446) 171 (0.9%) View
Total: 10 Total: 18297 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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