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1158  structures 9078  species 0  interactions 220434  sequences 877  architectures

Clan: THDP-binding (CL0254)


Thiamin diphosphate-binding superfamily Add an annotation

This clan includes pyruvate dehydrogenases, branched chain alpha-keto acid decarboxylases, phosphoketolases and the pyrimidine binding region of transketolases.

This clan contains 10 families and the total number of domains in the clan is 220434. The clan was built by J Mistry and A Bateman.

Literature references

  1. Meile L, Rohr LM, Geissmann TA, Herensperger M, Teuber M; , J Bacteriol 2001;183:2929-2936.: Characterization of the D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase gene (xfp) from Bifidobacterium lactis. PUBMED:11292814 EPMC:11292814
  2. Lindqvist Y, Schneider G, Ermler U, Sundstrom M; , EMBO J 1992;11:2373-2379.: Three-dimensional structure of transketolase, a thiamine diphosphate dependent enzyme, at 2.5 A resolution. PUBMED:1628611 EPMC:1628611


This clan contains the following 10 member families:

DXP_synthase_N E1_dh PDH_E1_M POR_N TPP_enzyme_C TPP_enzyme_N Transket_pyr Transketolase_N XFP XFP_N

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Transket_pyr (PF02779) 52255 (23.7%) View
TPP_enzyme_C (PF02775) 48448 (22.0%) View
TPP_enzyme_N (PF02776) 37963 (17.2%) View
E1_dh (PF00676) 28831 (13.1%) View
Transketolase_N (PF00456) 21539 (9.8%) View
POR_N (PF01855) 10066 (4.6%) View
DXP_synthase_N (PF13292) 9827 (4.5%) View
PDH_E1_M (PF17831) 4442 (2.0%) View
XFP_N (PF09364) 3562 (1.6%) View
XFP (PF03894) 3501 (1.6%) View
Total: 10 Total: 220434 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...