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8  structures 4876  species 0  interactions 10641  sequences 117  architectures

Clan: TIKI (CL0572)


Tiki-like, or EreA-ChaN-like 2His 2Glu metallopreotease SF Add an annotation

TIKI superfamily proteins carry a core fold contributing to the enzymic activity, that ranges from metalloprotease, erythromycin esterase and bacterial toinosis as in the MARTX and dermonecrotic toxin families, amongst others. All superfamily members carry the active site residues of two histidines and two glutamates [1]. Tiki proteins themselves antagonize Wnt activity upstream of its receptor.

This clan contains 3 families and the total number of domains in the clan is 10641. The clan was built by P Coggill.

Literature references

  1. Sanchez-Pulido L, Ponting CP;, Bioinformatics. 2013;29:2371-2374.: Tiki, at the head of a new superfamily of enzymes. PUBMED:23868957 EPMC:23868957


This clan contains the following 3 member families:

Cofac_haem_bdg Erythro_esteras TraB_PrgY_gumN

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
TraB_PrgY_gumN (PF01963) 5955 (56.0%) View
Erythro_esteras (PF05139) 2732 (25.7%) View
Cofac_haem_bdg (PF04187) 1954 (18.4%) View
Total: 3 Total: 10641 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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