Powering down the Pfam website
On October 5th, we began redirecting traffic from Pfam (pfam.xfam.org) to InterPro (www.ebi.ac.uk/interpro). The Pfam website will remain available at pfam-legacy.xfam.org until January 2023, when it will be decommissioned. You can read more about the sunset period in our blog post.

Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
295  structures 1943  species 0  interactions 36140  sequences 1393  architectures

Clan: TSP3 (CL0689)


Thrombospondin type 3 repeat superfamily Add an annotation

This superfamily includes short calcium binding repeats.

This clan contains 4 families and the total number of domains in the clan is 36140. The clan was built by A Bateman.


This clan contains the following 4 member families:

Binary_toxB DUF4270 TSP3_bac TSP_3

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
TSP_3 (PF02412) 28523 (78.9%) View
TSP3_bac (PF18884) 6555 (18.1%) View
DUF4270 (PF14092) 1016 (2.8%) View
Binary_toxB (PF03495) 46 (0.1%) View
Total: 4 Total: 36140 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...