Summary
TetR protein, C-terminal domain-like
This clan features families of transcriptional regulators for multidrug efflux pumps, which belong to the TetR superfamily. They are induced by the presence of a variety of factors, such as antibiotics or organic solvents. The C-terminal region featured in these families is thought to contain the inducer-binding site; the divergent sequences in this region allow for the binding of a variety of different inducers [1-4].
This clan contains 42 families and the total number of domains in the clan is 94481. The clan was built by M Fenech.
Literature references
- Rouch DA, Cram DS, DiBerardino D, Littlejohn TG, Skurray RA; , Mol Microbiol 1990;4:2051-2062.: Efflux-mediated antiseptic resistance gene qacA from Staphylococcus aureus: common ancestry with tetracycline- and sugar-transport proteins. PUBMED:2089219 EPMC:2089219
- Grkovic S, Brown MH, Roberts NJ, Paulsen IT, Skurray RA; , J Biol Chem 1998;273:18665-18673.: QacR is a repressor protein that regulates expression of the Staphylococcus aureus multidrug efflux pump QacA. PUBMED:9660841 EPMC:9660841
- Godsey MH, Zheleznova Heldwein EE, Brennan RG; , J Biol Chem 2002;277:40169-40172.: Structural biology of bacterial multidrug resistance gene regulators. PUBMED:12186881 EPMC:12186881
- Hillen W, Berens C; , Annu Rev Microbiol 1994;48:345-369.: Mechanisms underlying expression of Tn10 encoded tetracycline resistance. PUBMED:7826010 EPMC:7826010
Members
This clan contains the following 42 member families:
CecR_C COQ9 LuxT_C TetR TetR_C_1 TetR_C_10 TetR_C_11 TetR_C_12 TetR_C_13 TetR_C_14 TetR_C_15 TetR_C_16 TetR_C_17 TetR_C_18 TetR_C_19 TetR_C_2 TetR_C_20 TetR_C_21 TetR_C_22 TetR_C_23 TetR_C_24 TetR_C_25 TetR_C_26 TetR_C_27 TetR_C_28 TetR_C_29 TetR_C_3 TetR_C_30 TetR_C_31 TetR_C_32 TetR_C_33 TetR_C_34 TetR_C_35 TetR_C_36 TetR_C_37 TetR_C_38 TetR_C_4 TetR_C_5 TetR_C_6 TetR_C_7 TetR_C_8 TetR_C_9External database links
| SCOP: | 48498 |
Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
| Pfam family | Num. domains | Alignment |
|---|---|---|
| TetR_C_24 (PF17932) | 9916 (10.5%) | View |
| TetR_C_33 (PF13305) | 9881 (10.5%) | View |
| TetR_C_1 (PF02909) | 9402 (10.0%) | View |
| TetR_C_6 (PF13977) | 9350 (9.9%) | View |
| TetR_C_11 (PF16859) | 7935 (8.4%) | View |
| TetR_C_7 (PF14246) | 5301 (5.6%) | View |
| TetR_C_14 (PF17754) | 4493 (4.8%) | View |
| TetR_C_8 (PF14278) | 4036 (4.3%) | View |
| TetR_C_13 (PF16925) | 3572 (3.8%) | View |
| TetR_C_16 (PF17920) | 2647 (2.8%) | View |
| COQ9 (PF08511) | 2397 (2.5%) | View |
| TetR_C_31 (PF17940) | 2312 (2.4%) | View |
| TetR_C_32 (PF19344) | 2170 (2.3%) | View |
| TetR_C_29 (PF17938) | 1961 (2.1%) | View |
| TetR_C_30 (PF17939) | 1730 (1.8%) | View |
| TetR_C_28 (PF17937) | 1524 (1.6%) | View |
| TetR_C_3 (PF08362) | 1507 (1.6%) | View |
| TetR_C_15 (PF17918) | 1196 (1.3%) | View |
| TetR_C_4 (PF08359) | 1088 (1.2%) | View |
| TetR_C_27 (PF17935) | 1082 (1.1%) | View |
| TetR_C_22 (PF17928) | 1044 (1.1%) | View |
| TetR (PF13972) | 1033 (1.1%) | View |
| continued | ||
| Pfam family | Num. domains | Alignment |
|---|---|---|
| TetR_C_23 (PF17931) | 959 (1.0%) | View |
| TetR_C_21 (PF17926) | 945 (1.0%) | View |
| TetR_C_2 (PF08361) | 928 (1.0%) | View |
| TetR_C_20 (PF17925) | 920 (1.0%) | View |
| CecR_C (PF09209) | 805 (0.9%) | View |
| TetR_C_34 (PF17929) | 707 (0.7%) | View |
| TetR_C_35 (PF18556) | 686 (0.7%) | View |
| TetR_C_10 (PF16295) | 529 (0.6%) | View |
| TetR_C_25 (PF17933) | 416 (0.4%) | View |
| TetR_C_38 (PF19352) | 369 (0.4%) | View |
| TetR_C_19 (PF17924) | 285 (0.3%) | View |
| TetR_C_17 (PF17922) | 256 (0.3%) | View |
| TetR_C_36 (PF18598) | 228 (0.2%) | View |
| TetR_C_5 (PF08360) | 220 (0.2%) | View |
| TetR_C_18 (PF17923) | 139 (0.1%) | View |
| TetR_C_9 (PF14514) | 135 (0.1%) | View |
| TetR_C_26 (PF17934) | 127 (0.1%) | View |
| LuxT_C (PF18285) | 95 (0.1%) | View |
| TetR_C_37 (PF18665) | 87 (0.1%) | View |
| TetR_C_12 (PF16914) | 68 (0.1%) | View |
| Total: 42 | Total: 94481 |
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Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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