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614  structures 7647  species 0  interactions 94481  sequences 265  architectures

Clan: TetR_C (CL0174)

Summary

TetR protein, C-terminal domain-like Add an annotation

This clan features families of transcriptional regulators for multidrug efflux pumps, which belong to the TetR superfamily. They are induced by the presence of a variety of factors, such as antibiotics or organic solvents. The C-terminal region featured in these families is thought to contain the inducer-binding site; the divergent sequences in this region allow for the binding of a variety of different inducers [1-4].

This clan contains 42 families and the total number of domains in the clan is 94481. The clan was built by M Fenech.

Literature references

  1. Rouch DA, Cram DS, DiBerardino D, Littlejohn TG, Skurray RA; , Mol Microbiol 1990;4:2051-2062.: Efflux-mediated antiseptic resistance gene qacA from Staphylococcus aureus: common ancestry with tetracycline- and sugar-transport proteins. PUBMED:2089219 EPMC:2089219
  2. Grkovic S, Brown MH, Roberts NJ, Paulsen IT, Skurray RA; , J Biol Chem 1998;273:18665-18673.: QacR is a repressor protein that regulates expression of the Staphylococcus aureus multidrug efflux pump QacA. PUBMED:9660841 EPMC:9660841
  3. Godsey MH, Zheleznova Heldwein EE, Brennan RG; , J Biol Chem 2002;277:40169-40172.: Structural biology of bacterial multidrug resistance gene regulators. PUBMED:12186881 EPMC:12186881
  4. Hillen W, Berens C; , Annu Rev Microbiol 1994;48:345-369.: Mechanisms underlying expression of Tn10 encoded tetracycline resistance. PUBMED:7826010 EPMC:7826010

Members

This clan contains the following 42 member families:

CecR_C COQ9 LuxT_C TetR TetR_C_1 TetR_C_10 TetR_C_11 TetR_C_12 TetR_C_13 TetR_C_14 TetR_C_15 TetR_C_16 TetR_C_17 TetR_C_18 TetR_C_19 TetR_C_2 TetR_C_20 TetR_C_21 TetR_C_22 TetR_C_23 TetR_C_24 TetR_C_25 TetR_C_26 TetR_C_27 TetR_C_28 TetR_C_29 TetR_C_3 TetR_C_30 TetR_C_31 TetR_C_32 TetR_C_33 TetR_C_34 TetR_C_35 TetR_C_36 TetR_C_37 TetR_C_38 TetR_C_4 TetR_C_5 TetR_C_6 TetR_C_7 TetR_C_8 TetR_C_9

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
TetR_C_24 (PF17932) 9916 (10.5%) View
TetR_C_33 (PF13305) 9881 (10.5%) View
TetR_C_1 (PF02909) 9402 (10.0%) View
TetR_C_6 (PF13977) 9350 (9.9%) View
TetR_C_11 (PF16859) 7935 (8.4%) View
TetR_C_7 (PF14246) 5301 (5.6%) View
TetR_C_14 (PF17754) 4493 (4.8%) View
TetR_C_8 (PF14278) 4036 (4.3%) View
TetR_C_13 (PF16925) 3572 (3.8%) View
TetR_C_16 (PF17920) 2647 (2.8%) View
COQ9 (PF08511) 2397 (2.5%) View
TetR_C_31 (PF17940) 2312 (2.4%) View
TetR_C_32 (PF19344) 2170 (2.3%) View
TetR_C_29 (PF17938) 1961 (2.1%) View
TetR_C_30 (PF17939) 1730 (1.8%) View
TetR_C_28 (PF17937) 1524 (1.6%) View
TetR_C_3 (PF08362) 1507 (1.6%) View
TetR_C_15 (PF17918) 1196 (1.3%) View
TetR_C_4 (PF08359) 1088 (1.2%) View
TetR_C_27 (PF17935) 1082 (1.1%) View
TetR_C_22 (PF17928) 1044 (1.1%) View
TetR (PF13972) 1033 (1.1%) View
continued
Pfam family Num. domains Alignment
TetR_C_23 (PF17931) 959 (1.0%) View
TetR_C_21 (PF17926) 945 (1.0%) View
TetR_C_2 (PF08361) 928 (1.0%) View
TetR_C_20 (PF17925) 920 (1.0%) View
CecR_C (PF09209) 805 (0.9%) View
TetR_C_34 (PF17929) 707 (0.7%) View
TetR_C_35 (PF18556) 686 (0.7%) View
TetR_C_10 (PF16295) 529 (0.6%) View
TetR_C_25 (PF17933) 416 (0.4%) View
TetR_C_38 (PF19352) 369 (0.4%) View
TetR_C_19 (PF17924) 285 (0.3%) View
TetR_C_17 (PF17922) 256 (0.3%) View
TetR_C_36 (PF18598) 228 (0.2%) View
TetR_C_5 (PF08360) 220 (0.2%) View
TetR_C_18 (PF17923) 139 (0.1%) View
TetR_C_9 (PF14514) 135 (0.1%) View
TetR_C_26 (PF17934) 127 (0.1%) View
LuxT_C (PF18285) 95 (0.1%) View
TetR_C_37 (PF18665) 87 (0.1%) View
TetR_C_12 (PF16914) 68 (0.1%) View
Total: 42 Total: 94481
No alignment ℹ
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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