Powering down the Pfam website
On October 5th, we began redirecting traffic from Pfam (pfam.xfam.org) to InterPro (www.ebi.ac.uk/interpro). The Pfam website will remain available at pfam-legacy.xfam.org until January 2023, when it will be decommissioned. You can read more about the sunset period in our blog post.

Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
70  structures 1428  species 0  interactions 30836  sequences 338  architectures

Clan: Tetraspannin (CL0347)


Tetraspannin-like Add an annotation

This clan includes the tetraspanin family which contains four transmembrane regions. The CD20 family also has four transmembrane regions, but its members are not considered true tetraspanins as they lack nearly all of the key functional tetraspanin residues [1].

This clan contains 6 families and the total number of domains in the clan is 30836. The clan was built by J Mistry and RD Finn.

Literature references

  1. Hemler ME;, J Cell Biol. 2001;155:1103-1107.: Specific tetraspanin functions. PUBMED:11756464 EPMC:11756464


This clan contains the following 6 member families:

CD20 DUF2569 DUF4064 DUF4728 Mtp Tetraspanin

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Tetraspanin (PF00335) 23554 (76.4%) View
CD20 (PF04103) 4706 (15.3%) View
Mtp (PF03821) 1329 (4.3%) View
DUF4728 (PF15860) 536 (1.7%) View
DUF2569 (PF10754) 407 (1.3%) View
DUF4064 (PF13273) 304 (1.0%) View
Total: 6 Total: 30836 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...