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7  structures 1555  species 0  interactions 11853  sequences 170  architectures

Clan: Traffic (CL0147)


Trafficking protein Add an annotation

The members of this clan are involved in protein trafficking. The Sec20 family are integral membrane proteins involved in ER to Golgi transport [1] and V-SNARES are involved in membrane fusion [2].

This clan contains 3 families and the total number of domains in the clan is 11853. The clan was built by J Mistry.

Literature references

  1. Fischer von Mollard G, Stevens TH; , Mol Biol Cell 1999;10:1719-1732.: The Saccharomyces cerevisiae v-SNARE Vti1p is required for multiple membrane transport pathways to the vacuole. PUBMED:10359592 EPMC:10359592
  2. Sweet DJ, Pelham HR; , EMBO J 1993;12:2831-2840.: The TIP1 gene of Saccharomyces cerevisiae encodes an 80 kDa cytoplasmic protein that interacts with the cytoplasmic domain of Sec20p. PUBMED:8334998 EPMC:8334998


This clan contains the following 3 member families:


Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
V-SNARE_C (PF12352) 6843 (57.7%) View
V-SNARE (PF05008) 2864 (24.2%) View
Sec20 (PF03908) 2146 (18.1%) View
Total: 3 Total: 11853 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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