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11  structures 2315  species 0  interactions 16682  sequences 202  architectures

Clan: Tubby_C (CL0395)


Tubby C-terminal domain-like Add an annotation

This superfamily contains the scramblase protein family, the Tub family and the DUF567, a family of plant and bacterial proteins of hitherto unknown function. All members are membrane-tethered transcription factors.

This clan contains 4 families and the total number of domains in the clan is 16682. The clan was built by A Bateman.

Literature references

  1. Bateman A, Finn RD, Sims PJ, Wiedmer T, Biegert A, Soding J;, Bioinformatics. 2009;25:159-162.: Phospholipid scramblases and Tubby-like proteins belong to a new superfamily of membrane tethered transcription factors. PUBMED:19010806 EPMC:19010806


This clan contains the following 4 member families:

DUF3527 LOR Scramblase Tub

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Tub (PF01167) 5684 (34.1%) View
LOR (PF04525) 5243 (31.4%) View
Scramblase (PF03803) 4084 (24.5%) View
DUF3527 (PF12043) 1671 (10.0%) View
Total: 4 Total: 16682 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...