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22  structures 1417  species 0  interactions 42299  sequences 755  architectures

Clan: WRKY-GCM1 (CL0274)


WRKY-GCM1 superfamily Add an annotation

WRKY and GCM1 are metal chelating DNA-binding domains (DBD) which share a four stranded fold [1]. We present evidence that they share a stabilising core, which suggests a possible origin from a BED finger-like intermediate that was in turn ultimately derived from a C2H2 Zn-finger domain [1].

This clan contains 7 families and the total number of domains in the clan is 42299. The clan was built by A Bateman.

Literature references

  1. Babu MM, Iyer LM, Balaji S, Aravind L; , Nucleic Acids Res. 2006; [Epub ahead of print]: The natural history of the WRKY-GCM1 zinc fingers and the relationship between transcription factors and transposons. PUBMED:17130173 EPMC:17130173


This clan contains the following 7 member families:


External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
WRKY (PF03106) 18534 (43.8%) View
FAR1 (PF03101) 10156 (24.0%) View
DBD_Tnp_Mut (PF03108) 5335 (12.6%) View
FLYWCH (PF04500) 4567 (10.8%) View
Gti1_Pac2 (PF09729) 2809 (6.6%) View
GCM (PF03615) 693 (1.6%) View
AFT (PF08731) 205 (0.5%) View
Total: 7 Total: 42299 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...