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45  structures 8297  species 0  interactions 49410  sequences 500  architectures

Clan: pap2 (CL0525)


Acid phosphatase/Vanadium-dependent haloperoxidase Add an annotation

The PAP2 superfamily is characterised by being mult-helical, with the core consisting of a 5-helical bundle. Normally the family will bind cofactor at the beginning of the third helix. The superfamily includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:, Phosphatidylglycerophosphatase B EC: and bacterial acid phosphatase EC: The family also includes a variety of haloperoxidases [1,2] that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.

This clan contains 6 families and the total number of domains in the clan is 49410. The clan was built by P Coggill.

Literature references

  1. Stukey J, Carman GM; , Protein Sci 1997;6:469-472.: Identification of a novel phosphatase sequence motif. PUBMED:9041652 EPMC:9041652
  2. Neuwald AF; , Protein Sci 1997;6:1764-1767.: An unexpected structural relationship between integral membrane phosphatases and soluble haloperoxidases. PUBMED:9260289 EPMC:9260289
  3. Messerschmidt A, Wever R; , Proc Natl Acad Sci U S A 1996;93:392-396.: X-ray structure of a vanadium-containing enzyme: chloroperoxidase from the fungus Curvularia inaequalis. PUBMED:8552646 EPMC:8552646


This clan contains the following 6 member families:

DUF212 PAP2 PAP2_3 PAP2_C Scs3p VCPO_N

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PAP2 (PF01569) 36601 (74.1%) View
PAP2_3 (PF14378) 5527 (11.2%) View
PAP2_C (PF14360) 3106 (6.3%) View
DUF212 (PF02681) 2571 (5.2%) View
Scs3p (PF10261) 1538 (3.1%) View
VCPO_N (PF17897) 67 (0.1%) View
Total: 6 Total: 49410 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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