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207  structures 483  species 0  interactions 15682  sequences 162  architectures

Clan: uPAR_Ly6_toxin (CL0117)


uPAR/Ly6/CD59/snake toxin-receptor superfamily Add an annotation

This superfamily contains snake toxins as well as extracellular cysteine rich domains.

This clan contains 10 families and the total number of domains in the clan is 15682. The clan was built by A Bateman.


This clan contains the following 10 member families:

Activin_recp BAMBI DUF5746 ecTbetaR2 Ly-6_related PLA2_inh QVR Toxin_TOLIP UPAR_LY6 UPAR_LY6_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Activin_recp (PF01064) 5479 (34.9%) View
UPAR_LY6 (PF00021) 5051 (32.2%) View
QVR (PF17064) 1843 (11.8%) View
ecTbetaR2 (PF08917) 750 (4.8%) View
UPAR_LY6_2 (PF16975) 731 (4.7%) View
Toxin_TOLIP (PF00087) 623 (4.0%) View
Ly-6_related (PF06579) 514 (3.3%) View
BAMBI (PF06211) 363 (2.3%) View
PLA2_inh (PF02988) 297 (1.9%) View
DUF5746 (PF19017) 31 (0.2%) View
Total: 10 Total: 15682 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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