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384  structures 1598  species 0  interactions 141139  sequences 3317  architectures

Clan: zf-FYVE-PHD (CL0390)

Summary

FYVE/PHD zinc finger superfamily Add an annotation

Superfamily contains a number of zinc-fingers, of the FYVE/PHD type, which are found in several groups of proteins including myelin-associated oligodendrocytic basic proteins (MOBP) Rabphilins, melanophilins, exophilins and myosin-VIIA and Rab-interacting protein families.

This clan contains 13 families and the total number of domains in the clan is 141139. The clan was built by P Coggill.

Members

This clan contains the following 13 member families:

ADD_ATRX ADD_DNMT3 FYVE FYVE_2 PHD PHD_2 PHD_4 PHD_Oberon RAG2_PHD zf-HC5HC2H zf-HC5HC2H_2 zf-PHD-like zf-piccolo

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PHD (PF00628) 64429 (45.6%) View
FYVE (PF01363) 30324 (21.5%) View
zf-HC5HC2H_2 (PF13832) 13682 (9.7%) View
PHD_2 (PF13831) 9826 (7.0%) View
zf-HC5HC2H (PF13771) 6813 (4.8%) View
FYVE_2 (PF02318) 5868 (4.2%) View
PHD_4 (PF16866) 2309 (1.6%) View
zf-piccolo (PF05715) 2270 (1.6%) View
ADD_DNMT3 (PF17980) 2042 (1.4%) View
PHD_Oberon (PF07227) 1926 (1.4%) View
ADD_ATRX (PF17981) 944 (0.7%) View
zf-PHD-like (PF15446) 469 (0.3%) View
RAG2_PHD (PF13341) 237 (0.2%) View
Total: 13 Total: 141139 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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