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384  structures 1598  species 0  interactions 141139  sequences 3317  architectures

Clan: zf-FYVE-PHD (CL0390)


FYVE/PHD zinc finger superfamily Add an annotation

Superfamily contains a number of zinc-fingers, of the FYVE/PHD type, which are found in several groups of proteins including myelin-associated oligodendrocytic basic proteins (MOBP) Rabphilins, melanophilins, exophilins and myosin-VIIA and Rab-interacting protein families.

This clan contains 13 families and the total number of domains in the clan is 141139. The clan was built by P Coggill.


This clan contains the following 13 member families:

ADD_ATRX ADD_DNMT3 FYVE FYVE_2 PHD PHD_2 PHD_4 PHD_Oberon RAG2_PHD zf-HC5HC2H zf-HC5HC2H_2 zf-PHD-like zf-piccolo

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PHD (PF00628) 64429 (45.6%) View
FYVE (PF01363) 30324 (21.5%) View
zf-HC5HC2H_2 (PF13832) 13682 (9.7%) View
PHD_2 (PF13831) 9826 (7.0%) View
zf-HC5HC2H (PF13771) 6813 (4.8%) View
FYVE_2 (PF02318) 5868 (4.2%) View
PHD_4 (PF16866) 2309 (1.6%) View
zf-piccolo (PF05715) 2270 (1.6%) View
ADD_DNMT3 (PF17980) 2042 (1.4%) View
PHD_Oberon (PF07227) 1926 (1.4%) View
ADD_ATRX (PF17981) 944 (0.7%) View
zf-PHD-like (PF15446) 469 (0.3%) View
RAG2_PHD (PF13341) 237 (0.2%) View
Total: 13 Total: 141139 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...