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4  structures 103  species 0  interactions 10148  sequences 118  architectures

Family: 7tm_6 (PF02949)

Summary: 7tm Odorant receptor

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

7tm Odorant receptor Provide feedback

This family is composed of 7 transmembrane receptors, that are probably drosophila odorant receptors.

Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR004117

All known members of this group are seven-transmembrane proteins that are candidate odorant receptors in Drosophila.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Chemosens_recp (CL0176), which has the following description:

The members of this clan are families of various gustatory and odorant receptors. They are described as being seven-transmembrane receptors, and in fact all show characteristic regions of hydrophobicity on the alignment.

The clan contains the following 4 members:

7tm_6 7tm_7 DUF267 Trehalose_recp

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(36)
Full
(10148)
Representative proteomes UniProt
(20903)
RP15
(2484)
RP35
(4811)
RP55
(8972)
RP75
(10452)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(36)
Full
(10148)
Representative proteomes UniProt
(20903)
RP15
(2484)
RP35
(4811)
RP55
(8972)
RP75
(10452)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(36)
Full
(10148)
Representative proteomes UniProt
(20903)
RP15
(2484)
RP35
(4811)
RP55
(8972)
RP75
(10452)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_436 (release 6.4)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Bateman A
Number in seed: 36
Number in full: 10148
Average length of the domain: 254.6 aa
Average identity of full alignment: 14 %
Average coverage of the sequence by the domain: 75.61 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 25.8 25.8
Trusted cut-off 25.8 25.8
Noise cut-off 25.7 25.7
Model length: 313
Family (HMM) version: 23
Download: download the raw HMM for this family

Species distribution

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Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Tree controls

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The tree shows the occurrence of this domain across different species. More...

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Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the 7tm_6 domain has been found. There are 4 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A026W182 View 3D Structure Click here
A0A0B4KGT9 View 3D Structure Click here
E2BJ30 View 3D Structure Click here
O46077 View 3D Structure Click here
P81909 View 3D Structure Click here
P81910 View 3D Structure Click here
P81911 View 3D Structure Click here
P81912 View 3D Structure Click here
P81913 View 3D Structure Click here
P81914 View 3D Structure Click here
P81915 View 3D Structure Click here
P81916 View 3D Structure Click here
P81917 View 3D Structure Click here
P81918 View 3D Structure Click here
P81919 View 3D Structure Click here
P81921 View 3D Structure Click here
P81922 View 3D Structure Click here
P81923 View 3D Structure Click here
P82982 View 3D Structure Click here
P82983 View 3D Structure Click here
P82984 View 3D Structure Click here
P82985 View 3D Structure Click here
P82986 View 3D Structure Click here
Q16EI9 View 3D Structure Click here
Q178U6 View 3D Structure Click here
Q7QCC7 View 3D Structure Click here
Q8IRZ5 View 3D Structure Click here
Q8WTE6 View 3D Structure Click here
Q8WTE7 View 3D Structure Click here
Q9I816 View 3D Structure Click here
Q9V3N2 View 3D Structure Click here
Q9V568 View 3D Structure Click here
Q9V589 View 3D Structure Click here
Q9V6A9 View 3D Structure Click here
Q9V6H2 View 3D Structure Click here
Q9V8Y7 View 3D Structure Click here
Q9V9I2 View 3D Structure Click here
Q9V9I4 View 3D Structure Click here
Q9VAW0 View 3D Structure Click here
Q9VAZ3 View 3D Structure Click here