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0  structures 672  species 0  interactions 763  sequences 6  architectures

Family: PELOTA_1 (PF15608)

Summary: PELOTA RNA binding domain

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This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

PELOTA RNA binding domain Provide feedback

This RNA binding Pelota domain [1] is at the C-terminus of a PRTase family [2]. These PRTase+Pelota genes are found in the biosynthetic operon associated with the Ter stress-response operon and are predicted to be involved in the biosynthesis of a ribo-nucleoside involved in stress response [2].

Literature references

  1. Anantharaman V, Koonin EV, Aravind L;, Nucleic Acids Res. 2002;30:1427-1464.: Comparative genomics and evolution of proteins involved in RNA metabolism. PUBMED:11917006 EPMC:11917006

  2. Anantharaman V, Iyer LM, Aravind L;, Mol Biosyst. 2012;8:3142-3165.: Ter-dependent stress response systems: novel pathways related to metal sensing, production of a nucleoside-like metabolite, and DNA-processing. PUBMED:23044854 EPMC:23044854

Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR028157

This RNA-binding PELOTA domain [ PUBMED:11917006 ] is at the C terminus of a phosphoribosyltransferase (PRTase) family [ PUBMED:23044854 ]. These PRTase+Pelota genes are found in the biosynthetic operon associated with the Ter stress response operon, and are predicted to be involved in the biosynthesis of a ribo-nucleoside involved in stress response [ PUBMED:23044854 ]. However, at least one protein predicted to possess this domain ( SWISSPROT ) has been shown to posses cysteine protease activity [ PUBMED:24206355 ].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan PELOTA (CL0101), which has the following description:

The members of this clan are all involved in binding to ribose sugar of RNA[1]. Indeed, the key RNA binding residues are conserved across the different families [1]. Members of this clan form mixed alpha-helical and beta-sheet structures [1][2].

The clan contains the following 7 members:

eRF1_3 PELOTA_1 RbsD_FucU Ribosomal_L7Ae RNase_P_pop3 SpoU_sub_bind TSNR_N


We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

Representative proteomes UniProt
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

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Representative proteomes UniProt

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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...


This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Anantharaman V
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Anantharaman V
Number in seed: 36
Number in full: 763
Average length of the domain: 81.2 aa
Average identity of full alignment: 54 %
Average coverage of the sequence by the domain: 14.12 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 25.0 25.0
Trusted cut-off 25.0 25.0
Noise cut-off 24.9 24.8
Model length: 81
Family (HMM) version: 9
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence


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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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The tree shows the occurrence of this domain across different species. More...


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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
K0F8Y2 View 3D Structure Click here
Q6FAX7 View 3D Structure Click here