!!

Powering down the Pfam website
On October 5th, we began redirecting traffic from Pfam (pfam.xfam.org) to InterPro (www.ebi.ac.uk/interpro). The Pfam website will remain available at pfam-legacy.xfam.org until January 2023, when it will be decommissioned. You can read more about the sunset period in our blog post.

Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
35  structures 1598  species 0  interactions 214393  sequences 1423  architectures

Family: Mito_carr (PF00153)

Summary: Mitochondrial carrier protein

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Adenine nucleotide translocator". More...

Adenine nucleotide translocator Edit Wikipedia article

solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
Identifiers
SymbolSLC25A4
Alt. symbolsPEO3, PEO2, ANT1
NCBI gene291
HGNC10990
OMIM103220
RefSeqNM_001151
UniProtP12235
Other data
LocusChr. 4 q35
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
Identifiers
SymbolSLC25A5
Alt. symbolsANT2
NCBI gene292
HGNC10991
OMIM300150
RefSeqNM_001152
UniProtP05141
Other data
LocusChr. X q24-q26
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
Identifiers
SymbolSLC25A6
Alt. symbolsANT3
NCBI gene293
HGNC10992
OMIM403000
RefSeqNM_001636
UniProtP12236

Adenine nucleotide translocator is a mitochondrial protein.

External links

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This is the Wikipedia entry entitled "Mitochondrial carrier". More...

Mitochondrial carrier Edit Wikipedia article

A mitochondrial carrier is a protein in the solute carrier family which transfers molecules across the membranes of the mitochondria.

Examples include:


This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Mitochondrial carrier protein Provide feedback

No Pfam abstract.

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR018108

A variety of substrate carrier proteins that are involved in energy transfer are found in the inner mitochondrial membrane or integral to the membrane of other eukaryotic organelles such as the peroxisome [ PUBMED:2158156 , PUBMED:8140286 , PUBMED:8487299 , PUBMED:8206158 , PUBMED:8291088 ]. Such proteins include: ADP, ATP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrier protein; phosphate carrier protein; tricarboxylate transport protein (or citrate transport protein); Graves disease carrier protein; yeast mitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein; and many others. Structurally, these proteins can consist of up to three tandem repeats of a domain of approximately 100 residues, each domain containing two transmembrane regions.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

Loading domain graphics...

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(160)
Full
(214393)
Representative proteomes UniProt
(348951)
RP15
(39690)
RP35
(94737)
RP55
(163718)
RP75
(221328)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(160)
Full
(214393)
Representative proteomes UniProt
(348951)
RP15
(39690)
RP35
(94737)
RP55
(163718)
RP75
(221328)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(160)
Full
(214393)
Representative proteomes UniProt
(348951)
RP15
(39690)
RP35
(94737)
RP55
(163718)
RP75
(221328)
Raw Stockholm Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: mito_carr;
Type: Repeat
Sequence Ontology: SO:0001068
Author: Sonnhammer ELL
Number in seed: 160
Number in full: 214393
Average length of the domain: 94.2 aa
Average identity of full alignment: 21 %
Average coverage of the sequence by the domain: 71.69 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 22.3 22.3
Trusted cut-off 22.3 22.3
Noise cut-off 22.2 22.2
Model length: 97
Family (HMM) version: 30
Download: download the raw HMM for this family

Species distribution

Sunburst controls

Hide

Weight segments by...


Change the size of the sunburst

Small
Large

Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

Generate a FASTA-format file

Clear selection

This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

Loading sunburst data...

Tree controls

Hide

The tree shows the occurrence of this domain across different species. More...

Loading...

Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Mito_carr domain has been found. There are 35 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

Loading structure mapping...

AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A044QPR5 View 3D Structure Click here
A0A044R2A5 View 3D Structure Click here
A0A044RAP0 View 3D Structure Click here
A0A044RC53 View 3D Structure Click here
A0A044RZ47 View 3D Structure Click here
A0A044SAZ5 View 3D Structure Click here
A0A044SC81 View 3D Structure Click here
A0A044SFM9 View 3D Structure Click here
A0A044T385 View 3D Structure Click here
A0A044T7A8 View 3D Structure Click here
A0A044T8Z5 View 3D Structure Click here
A0A044TJR6 View 3D Structure Click here
A0A044TTL1 View 3D Structure Click here
A0A044UKJ0 View 3D Structure Click here
A0A044UT65 View 3D Structure Click here
A0A044UTC6 View 3D Structure Click here
A0A044V7C9 View 3D Structure Click here
A0A044V9N0 View 3D Structure Click here
A0A044VA94 View 3D Structure Click here
A0A044VJC9 View 3D Structure Click here
A0A044VJE3 View 3D Structure Click here
A0A077YXK9 View 3D Structure Click here
A0A077YYV9 View 3D Structure Click here
A0A077YZ30 View 3D Structure Click here
A0A077YZA5 View 3D Structure Click here
A0A077Z074 View 3D Structure Click here
A0A077Z205 View 3D Structure Click here
A0A077Z248 View 3D Structure Click here
A0A077Z2J7 View 3D Structure Click here
A0A077Z3T2 View 3D Structure Click here
A0A077Z3W8 View 3D Structure Click here
A0A077Z592 View 3D Structure Click here
A0A077Z6W9 View 3D Structure Click here
A0A077Z747 View 3D Structure Click here
A0A077ZAH6 View 3D Structure Click here
A0A077ZD39 View 3D Structure Click here
A0A077ZE15 View 3D Structure Click here
A0A077ZEY2 View 3D Structure Click here
A0A077ZF28 View 3D Structure Click here
A0A077ZGV1 View 3D Structure Click here