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95  structures 1525  species 0  interactions 4285  sequences 58  architectures

Family: YEATS (PF03366)

Summary: YEATS family

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "YEATS domain". More...

YEATS domain Edit Wikipedia article

YEATS domain

YEATS domain

In molecular biology, the YEATS domain is a protein domain found in a variety of proteins from eukaryotic organisms.[1] YEATS domain proteins are found in a variety of chromatin modification molecular complexes. Structurally the domain has an immunoglobulin like fold.[2] The YEATS domain has shown to bind to acetyllysine protein modifications. For example, the YEATS domain of yeast Af9 protein.[3] The YEATS domain has shown to be a reader domain for the protein modification of lysine crotonylation.[4]

See also



  1. ^ Schulze JM, Wang AY, Kobor MS (2009). "YEATS domain proteins: a diverse family with many links to chromatin modification and transcription". Biochem. Cell Biol. 87 (1): 65–75. doi:10.1139/O08-111. PMID 19234524.
  2. ^ Wang AY, Schulze JM, Skordalakes E, Gin JW, Berger JM, Rine J, Kobor MS (2009). "Asf1-like structure of the conserved Yaf9 YEATS domain and role in H2A.Z deposition and acetylation". Proc. Natl. Acad. Sci. U.S.A. 106 (51): 21573–8. doi:10.1073/pnas.0906539106. PMC 2799888. PMID 19966225.
  3. ^ Li Y, Wen H, Xi Y, Tanaka K, Wang H, Peng D, Ren Y, Jin Q, Dent SY, Li W, Li H, Shi X (2014). "AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylation". Cell. 159 (3): 558–71. doi:10.1016/j.cell.2014.09.049. PMC 4344132. PMID 25417107.
  4. ^ Andrews FH, Shinsky SA, Shanle EK, Bridgers JB, Gest A, Tsun IK, Krajewski K, Shi X, Strahl BD, Kutateladze TG (2016). "The Taf14 YEATS domain is a reader of histone crotonylation". Nat. Chem. Biol. 12 (6): 396–8. doi:10.1038/nchembio.2065. PMID 27089029.

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

YEATS family Provide feedback

We have named this family the YEATS family, after `YNK7', `ENL', `AF-9', and `TFIIF small subunit'. This family also contains the GAS41 protein. All these proteins are thought to have a transcription stimulatory activity

Literature references

  1. Harborth J, Weber K, Osborn M; , J Biol Chem 2000;275:31979-31985.: GAS41, a highly conserved protein in eukaryotic nuclei, binds to NuMA. PUBMED:10913114 EPMC:10913114

  2. Schreiner S, Birke M, Garcia-Cuellar MP, Zilles O, Greil J, Slany RK; , Cancer Res 2001;61:6480-6486.: MLL-ENL causes a reversible and myc-dependent block of myelomonocytic cell differentiation. PUBMED:11522644 EPMC:11522644

  3. Hemenway CS, de Erkenez AC, Gould GC; , Oncogene 2001;20:3798-3805.: The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias. PUBMED:11439343 EPMC:11439343

Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR005033

This family is named after YEATS (Yaf9, ENL, AF9, Taf14, and Sas5), an evolutionarily conserved module present in 4 proteins (ENL, AF9, GAS41, and YEATS2) in humans and 3 proteins (Sas5, Taf14, and Yaf9) in yeast. These proteins are found in major chromatin-remodeling and histone acetyl-transferase (HAT) complexes and implicated in regulation of chromatin structure, histone acetylation and deposition, gene transcription and DNA damage response. The YEATS domain, which as previously shown is found in a number of chromatin-associated proteins, has recently been shown to have the capacity to bind histone lysine acetylation [ PUBMED:27545619 ]. The ability of the YEATS domains of human AF9 and yeast Taf14 to recognise the histone mark H3K9ac, have shown that these proteins are members of the family of acetyllysine readers [ PUBMED:26341557 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan C2 (CL0154), which has the following description:

This superfamily includes C2 domains and C2-like domains.

The clan contains the following 18 members:

Aida_C2 Anillin B9-C2 C2 C2-C2_1 CC2D2AN-C2 CEP76-C2 DOCK-C2 IcmF_C MNNL NT-C2 PI3K_C2 PTEN_C2 pYEATS RPGR1_C SPATA6 Spond_N YEATS


We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

Representative proteomes UniProt
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PP/heatmap 1 View           

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

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Representative proteomes UniProt

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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

Representative proteomes UniProt
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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...


This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_2273 (release 6.6)
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Mifsud W
Number in seed: 218
Number in full: 4285
Average length of the domain: 81 aa
Average identity of full alignment: 36 %
Average coverage of the sequence by the domain: 16.74 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 22.0 22.0
Trusted cut-off 22.2 22.2
Noise cut-off 21.8 21.5
Model length: 82
Family (HMM) version: 19
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence


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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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The tree shows the occurrence of this domain across different species. More...


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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the YEATS domain has been found. There are 95 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A044RGV4 View 3D Structure Click here
A0A044SA38 View 3D Structure Click here
A0A077ZG49 View 3D Structure Click here
A0A0A2V6P4 View 3D Structure Click here
A0A0D2DJX4 View 3D Structure Click here
A0A0D2FH50 View 3D Structure Click here
A0A0D2GST5 View 3D Structure Click here
A0A0K0E0C0 View 3D Structure Click here
A0A0K0EF18 View 3D Structure Click here
A0A0N4UDL8 View 3D Structure Click here
A0A0N4UG67 View 3D Structure Click here
A0A0R0IBU1 View 3D Structure Click here
A0A175VZ03 View 3D Structure Click here
A0A175W7C7 View 3D Structure Click here
A0A1C1C8T6 View 3D Structure Click here
A0A1C1CP64 View 3D Structure Click here
A0A1C1CZP4 View 3D Structure Click here
A0A1D8PH31 View 3D Structure Click here
A0A2R8QDF9 View 3D Structure Click here
A0A3P7DGN1 View 3D Structure Click here
A0A3Q0KQ97 View 3D Structure Click here
A0A5S6PCG3 View 3D Structure Click here
A0A5S6PCS5 View 3D Structure Click here
A2AM29 View 3D Structure Click here
A4HSW4 View 3D Structure Click here
A4I8X3 View 3D Structure Click here
B0S8H1 View 3D Structure Click here
B2RYE9 View 3D Structure Click here
B4FY75 View 3D Structure Click here
C0H4S5 View 3D Structure Click here
C0NFN4 View 3D Structure Click here
C0NY59 View 3D Structure Click here
C1HBY7 View 3D Structure Click here
D3ZBV9 View 3D Structure Click here
F1QAS4 View 3D Structure Click here
F1QAV3 View 3D Structure Click here
F4IPK2 View 3D Structure Click here
G4VEL9 View 3D Structure Click here
I1LI12 View 3D Structure Click here
I1LPV8 View 3D Structure Click here