# STOCKHOLM 1.0 #=GF ID COX17 #=GF AC PF05051.16 #=GF DE Cytochrome C oxidase copper chaperone (COX17) #=GF AU Moxon SJ;0000-0003-4644-1816 #=GF AU Mistry J;0000-0003-2479-5322 #=GF AU Wood V;0000-0001-6330-7526 #=GF SE Pfam-B_5838 (release 7.7) #=GF GA 24.90 24.90; #=GF TC 24.90 25.00; #=GF NC 24.80 24.80; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq #=GF TP Family #=GF WK Cytochrome_c_oxidase #=GF CL CL0351 #=GF RN [1] #=GF RM 12370308 #=GF RT Mammalian copper chaperone cox17p has an essential role in #=GF RT activation of cytochrome C oxidase and embryonic development. #=GF RA Takahashi Y, Kako K, Kashiwabara S, Takehara A, Inada Y, Arai H, #=GF RA Nakada K, Kodama H, Hayashi J, Baba T, Munekata E; #=GF RL Mol Cell Biol 2002;22:7614-7621. #=GF RN [2] #=GF RM 15465825 #=GF RT Yeast cox17 solution structure and Copper(I) binding. #=GF RA Abajian C, Yatsunyk LA, Ramirez BE, Rosenzweig AC; #=GF RL J Biol Chem 2004;279:53584-53592. #=GF DR INTERPRO; IPR007745; #=GF DR SO; 0100021; polypeptide_conserved_region; #=GF CC Cox17 is essential for the assembly of functional cytochrome c #=GF CC oxidase (CCO) and for delivery of copper ions to the #=GF CC mitochondrion for insertion into the enzyme in yeast [1]. The #=GF CC structure of Cox17 [2] shows the protein to have an unstructured #=GF CC N-terminal region followed by two helices and several #=GF CC unstructured C-terminal residues. The Cu(I) binding site has #=GF CC been modelled as two-coordinate with ligation by conserved #=GF CC residues Cys23 and Cys26. #=GF SQ 91 #=GS W7WYE1_TETTS/16-60 AC W7WYE1.1 #=GS A8XMM4_CAEBR/19-64 AC A8XMM4.1 #=GS Q1HQG9_AEDAE/32-77 AC Q1HQG9.1 #=GS B4GKP0_DROPE/52-98 AC B4GKP0.1 #=GS B4MAA0_DROVI/33-78 AC B4MAA0.1 #=GS J9LWT0_ACYPI/23-68 AC J9LWT0.2 #=GS C1EJ27_MICCC/12-57 AC C1EJ27.1 #=GS A7S423_NEMVE/19-64 AC A7S423.1 #=GS F4NXS4_BATDJ/26-71 AC F4NXS4.1 #=GS A0D9G5_PARTE/15-59 AC A0D9G5.1 #=GS A0E6J0_PARTE/13-57 AC A0E6J0.1 #=GS D7G6Q6_ECTSI/37-82 AC D7G6Q6.1 #=GS Q4MYK4_THEPA/30-75 AC Q4MYK4.1 #=GS D0NN32_PHYIT/20-64 AC D0NN32.1 #=GS D2VNA1_NAEGR/59-105 AC D2VNA1.1 #=GS Q9LKH0_CHLRE/34-81 AC Q9LKH0.1 #=GS A4S718_OSTLU/17-65 AC A4S718.1 #=GS D8SY03_SELML/15-60 AC D8SY03.1 #=GS D7KKD3_ARALL/27-72 AC D7KKD3.1 #=GS M0V8J9_HORVV/28-73 AC M0V8J9.1 #=GS D3BTG7_POLPP/19-64 AC D3BTG7.1 #=GS F0ZZA3_DICPU/18-63 AC F0ZZA3.1 #=GS A0A384KV75_PLAKH/21-66 AC A0A384KV75.1 #=GS Q4E5Z7_TRYCC/16-60 AC Q4E5Z7.1 #=GS E9ACL9_LEIMA/26-70 AC E9ACL9.1 #=GS A4H3N5_LEIBR/23-67 AC A4H3N5.1 #=GS Q582X7_TRYB2/15-59 AC Q582X7.1 #=GS C3ZMD9_BRAFL/19-64 AC C3ZMD9.1 #=GS A0A0V0S4U5_9BILA/18-63 AC A0A0V0S4U5.1 #=GS COX17_SCHPO/23-70 AC Q9P7Z7.1 #=GS Q6CBM0_YARLI/22-69 AC Q6CBM0.2 #=GS Q75FA3_ASHGO/17-64 AC Q75FA3.1 #=GS G8JXJ3_ERECY/11-58 AC G8JXJ3.1 #=GS H2ATY2_KAZAF/16-63 AC H2ATY2.1 #=GS G8ZVM3_TORDC/13-60 AC G8ZVM3.1 #=GS C5M612_CANTT/9-55 AC C5M612.1 #=GS G3AK87_SPAPN/8-54 AC G3AK87.1 #=GS G8BEV1_CANPC/10-56 AC G8BEV1.1 #=GS A5DUX2_LODEL/12-58 AC A5DUX2.1 #=GS Q6FVU0_CANGA/8-55 AC Q6FVU0.1 #=GS G0W7Z9_NAUDC/26-77 AC G0W7Z9.1 #=GS G0V5H8_NAUCC/25-75 AC G0V5H8.1 #=GS I2H207_TETBL/20-67 AC I2H207.1 #=GS C4R5F9_KOMPG/12-58 AC C4R5F9.1 #=GS Q6CJV4_KLULA/16-63 AC Q6CJV4.2 #=GS G3AYD7_CANTC/9-56 AC G3AYD7.1 #=GS A5DNS8_PICGU/6-52 AC A5DNS8.1 #=GS J7RPL3_KAZNA/16-67 AC J7RPL3.1 #=GS N1JEZ8_BLUG1/31-79 AC N1JEZ8.1 #=GS K1XDW0_MARBU/42-90 AC K1XDW0.1 #=GS S3DWF4_GLAL2/28-76 AC S3DWF4.1 #=GS U7Q612_SPOS1/27-76 AC U7Q612.1 #=GS C9SIU1_VERA1/21-70 AC C9SIU1.1 #=GS G2Q683_MYCTT/28-77 AC G2Q683.1 #=GS G0SCF7_CHATD/1033-1082 AC G0SCF7.1 #=GS J4WLE3_BEAB2/24-72 AC J4WLE3.1 #=GS G2YNA8_BOTF4/30-81 AC G2YNA8.1 #=GS G9NML9_HYPAI/25-74 AC G9NML9.1 #=GS G4MQM7_MAGO7/27-76 AC G4MQM7.1 #=GS J3NX05_GAET3/36-85 AC J3NX05.1 #=GS Q4WWZ9_ASPFU/27-76 AC Q4WWZ9.1 #=GS C5FYY1_ARTOC/31-81 AC C5FYY1.1 #=GS C0NKR2_AJECG/25-75 AC C0NKR2.1 #=GS S7ZDG1_PENO1/27-76 AC S7ZDG1.1 #=GS Q0TZC3_PHANO/22-71 AC Q0TZC3.1 #=GS M2LHH3_BAUPA/29-77 AC M2LHH3.1 #=GS R7YJ74_CONA1/24-73 AC R7YJ74.1 #=GS K2RNX6_MACPH/29-78 AC K2RNX6.1 #=GS G1XBL7_ARTOA/21-70 AC G1XBL7.1 #=GS B3RY56_TRIAD/11-56 AC B3RY56.1 #=GS F4S8S2_MELLP/40-93 AC F4S8S2.1 #=GS A0A0C4F8P0_PUCT1/16-68 AC A0A0C4F8P0.1 #=GS D8Q007_SCHCM/13-61 AC D8Q007.1 #=GS F8Q700_SERL3/38-87 AC F8Q700.1 #=GS I2FPZ3_USTH4/19-73 AC I2FPZ3.1 #=GS A8PUC8_MALGO/22-76 AC A8PUC8.1 #=GS S8G815_FOMPI/36-85 AC S8G815.1 #=GS L8WQ87_THACA/29-79 AC L8WQ87.1 #=GS G4TJK8_SERID/30-79 AC G4TJK8.1 #=GS K5X5K5_AGABU/32-80 AC K5X5K5.1 #=GS V2XBY6_MONRO/32-80 AC V2XBY6.1 #=GS D6RKZ8_COPC7/66-115 AC D6RKZ8.1 #=GS I4YH63_WALMC/19-73 AC I4YH63.1 #=GS Q5KCT7_CRYNJ/40-89 AC Q5KCT7.1 #=GS F2UKN1_SALR5/17-62 AC F2UKN1.1 #=GS E9G4G5_DAPPU/24-69 AC E9G4G5.1 #=GS S2J9W3_MUCC1/22-67 AC S2J9W3.1 #=GS A0A068YHI2_ECHMU/14-59 AC A0A068YHI2.1 #=GS H2XPZ5_CIOIN/33-78 AC H2XPZ5.1 #=GS T1K8S8_TETUR/18-63 AC T1K8S8.1 #=GS G3N946_GASAC/20-65 AC G3N946.1 W7WYE1_TETTS/16-60 KKLK....P....CCACPETKKLRDACVFNN.....G.EE........NCKDFIEAHKECLRSKGFN. A8XMM4_CAEBR/19-64 KKLK....P....CCACPETKRVRDVCIIEN.....G.EE........HCGKLIEAHKACMRAAGFNV Q1HQG9_AEDAE/32-77 PKCK....A....CCACPETKRVRDACIMER.....G.EE........QCGDLIEKHKQCMRDMGFNI B4GKP0_DROPE/52-98 ...KGNCGA....CCACPEAKQARDQCFVEH.....G.EE........HCLGVIDAYKKCMREAGFNI B4MAA0_DROVI/33-78 PKCK....A....CCACPETKRARDQCIVEN.....G.EE........NCTKLIEAHKQCMRDAGFNI J9LWT0_ACYPI/23-68 KKLK....A....CCACPDTKRVRDACIMEN.....G.EE........KCGHLIEAHKECMRKMGFNI C1EJ27_MICCC/12-57 KPKK....I....CCACPITKNARDACIPEH.....D.EE........KCKYLIEAHKQCLRDEGFDV A7S423_NEMVE/19-64 KKLK....A....CCACPVTKKARDACIVEH.....G.EE........KCSYLIEAHKQCMRDQGFNI F4NXS4_BATDJ/26-71 PKCK....P....CCACPDTRQIRDECVILN.....G.EE........QCTDLIKAHQDCMRSMGFNI A0D9G5_PARTE/15-59 QECK....A....CSACPETRQLRDECIIFN.....G.EE........QCKKEIENHKVCLKKYGFE. A0E6J0_PARTE/13-57 EPLR....P....CCACPDTRNLRDECIISF.....G.EE........KCSKEIENHKLCLKKLGFE. D7G6Q6_ECTSI/37-82 SGKK....I....CCSCPDTKAARDDCVIMN.....G.EE........ECKNFIEAHKECLRSEGFDI Q4MYK4_THEPA/30-75 SGKH....I....CCVCKETKQARDDCIAQN.....G.QE........QCKKFIEAHNKCLKDEGFTV D0NN32_PHYIT/20-64 .GKK....I....CCSCPTTKQARDLCIVNN.....G.QD........KCKDIIEAHKACLRSEGFTI D2VNA1_NAEGR/59-105 PQKK....I....CCSCPDIKKIRDSCLITH.....GEENV.......ECKYLISAYRLCLRDLGFT. Q9LKH0_CHLRE/34-81 KPKK....I....CCSCPDTKKLRDTCIAER.....G.EEH......AYCQALIEAHKACLRVEGFKV A4S718_OSTLU/17-65 KPKK....I....CCACPETKRARDECVVTH.....GADED......GACREKIEQHLKCLRAEGFDV D8SY03_SELML/15-60 PKKK....I....CCACPDTKKLRDECIAEH.....G.ED........ACGKWIDVHLRCLREEGFNV D7KKD3_ARALL/27-72 PKKR....I....CCACPDTKKLRDECIVEH.....G.ES........ACTKWIEAHLSCLRSEGFKV M0V8J9_HORVV/28-73 PKKK....I....CCACPDTKRLRDECIVQN.....G.ED........ACGKWIEAHRQCLRAEGFNV D3BTG7_POLPP/19-64 PKKK....I....CCACPDTKKLRDECILTN.....G.ED........KCFEFIEKHKMCLRAEGFDI F0ZZA3_DICPU/18-63 PKKK....M....CCACPETKKTRDECIVNN.....G.ED........KCAQFIEAHKACLRSEGFDV A0A384KV75_PLAKH/21-66 PKKK....I....CCVCLETKKLRDECIVKL.....G.EE........QCRKYIEDHNQCLRNEGFDV Q4E5Z7_TRYCC/16-60 PGCK....I....CCACPAERRARDECVILK.....GVD.........ACKDQVEAFYACLLREGFT. E9ACL9_LEIMA/26-70 PSCK....I....CCACPQERRTRDECTLLR.....NVD.........ECETEIEAFYACLRREGFS. A4H3N5_LEIBR/23-67 PGCK....I....CCACPQERRARDECILLK.....NMD.........ECEAEVSAFYACLLKEGFS. Q582X7_TRYB2/15-59 PACK....I....CCACPAERQARDECTLLK.....GVE.........ACQKEIGAFYKCLLHEGFS. C3ZMD9_BRAFL/19-64 PKLK....P....CCACPETKKVRDACIIEK.....G.EE........NCGDLIEAHKECMRSLGFNV A0A0V0S4U5_9BILA/18-63 KKPK....P....CCACPETRKARDECIVEK.....G.PD........SCKELIEAHRRCMKQFGFEI COX17_SCHPO/23-70 EKPK....P....CCACPETKQARDACMLQS.....S.NGP......IECAKLIEAHKKCMAQYGYEV Q6CBM0_YARLI/22-69 DKPK....P....CCVCKDEKAARDECLLFN.....GVDSD.......KCKPLISAYKECMKGFGFDI Q75FA3_ASHGO/17-64 DKPK....P....CCVCKPEKEARDSCLLFN.....GVDA....V...KCQELVQKYKDCMKGYGFEV G8JXJ3_ERECY/11-58 KRPK....P....CCVCKVEKESRDECLLFN.....GLES....T...KCKELVDKYRSCMKGYGFEI H2ATY2_KAZAF/16-63 EKPK....P....CCVCLTEKEARDQCLLFK.....GADD....G...KCKEYIEKYRMCMKSFGFEI G8ZVM3_TORDC/13-60 GKPK....P....CCVCLPEKDERDQCILFN.....GQDS....D...KCKVFIQEYRKCMESHGFKI C5M612_CANTT/9-55 SKPK....P....CCVCIDERKKRDECTLLK.....GIES....D...DCKPIIEQYKACMNSYGFT. G3AK87_SPAPN/8-54 SRPK....P....CCVCLDERKLRDECLLYK.....GLES....G...KCADVIKQYTDCMIGYGFK. G8BEV1_CANPC/10-56 QKPK....P....CCVCLDERKERDKCLLFH.....GAES....D...DCKSILEKYTSCMKSYGFT. A5DUX2_LODEL/12-58 NKPK....P....CCVCIKEREERDKCALFH.....GVSD....D...NCKPQLEAYWACMKSYNFQ. Q6FVU0_CANGA/8-55 DKPK....P....CCVCLPEKEARDQCLLFD.....GQES....A...KCKELIEKYKSCMKTYGFNI G0W7Z9_NAUDC/26-77 EKPK....P....CCVCKPEKEERDKCLLFN.....TDDSDSSLS...SCEEYIQKYKACMKGYGFEV G0V5H8_NAUCC/25-75 DKPK....P....CCVCKPEKEERDKCLLFN.....T.EADETPA...SCQEFIDKYKACMRGYGFEV I2H207_TETBL/20-67 EKPK....P....CCVCTEQKEERDQCILFN.....GQES....T...KCTEFINKYKECMKGYGFEI C4R5F9_KOMPG/12-58 SKPK....P....CCVCKPEKEARDQCLLIN.....GQDS....G...KCDDLISQYKVCMKGFGFD. Q6CJV4_KLULA/16-63 TKPK....P....CCVCKPEKEARDECLLFN.....GQES....G...KCDELIAKYKTCMKGYGFEV G3AYD7_CANTC/9-56 EKPK....P....CCVCLDEKKIRDACLLQN.....GQES....G...KCDSIISQYKVCMKGYGFEI A5DNS8_PICGU/6-52 EKPK....P....CCVCLEEKKKRDECLLFN.....GQES....G...KCNELIAQYKQCMKGFGFE. J7RPL3_KAZNA/16-67 ERPK....A....CCVCKDEKSARDECLLFK.....GTADDSGYV...KCKDLIEKYKSCMKGHGFEV N1JEZ8_BLUG1/31-79 SDVK....P....CCVCREEKAERDNCMLFS.....RAANPE..A...DCVTMIDKYKSCMAGYGFR. K1XDW0_MARBU/42-90 VKVK....P....CCVCKEEKASRDECMLFS.....NAPNPQ..K...DCATTIDKYKSCMAGFGFK. S3DWF4_GLAL2/28-76 AKVK....P....CCVCLDEKKTRDECMLFS.....NAKDPQ..Q...DCMSTIDKYKSCMKGFGFN. U7Q612_SPOS1/27-76 SKPK....P....CCVCTQEKSKRDECMLFS.....NAANPS..V...DCKSTIDQYRTCMAGFGFKV C9SIU1_VERA1/21-70 EKPK....P....CCVCKEEKSKRDECMLFS.....NAADPA..K...ACAPTIDAYKLCMKGFGFEV G2Q683_MYCTT/28-77 SKPK....P....CCVCKEEKSRRDECMLFS.....KSADPQ..K...DCQSTIEQYRSCMAGFGFKV G0SCF7_CHATD/1033-1082 NKPK....P....CCVCKEEKAKRDDCMLFS.....TASDPQ..K...DCQSTIEAYRACMAGYGFKV J4WLE3_BEAB2/24-72 .RPK....P....CCVCKDEKAKRDECMLFS.....GAKDPQ..A...DCKSFVQQYKSCMLGYGYKV G2YNA8_BOTF4/30-81 .KPKFLEKP....CCVCKDEKAARDECMLFS.....TAKDPQ..V...ACASMVEKYKSCMAGFGFN. G9NML9_HYPAI/25-74 SKPK....P....CCVCKDEKAKRDECMLFS.....TAKNPA..A...DCVSLVDQYKSCMQGFGFSV G4MQM7_MAGO7/27-76 NKPK....P....CCVCKDEKAARDECMLFS.....NAKDPA..E...DCKTKIEQYKSCMAGFGFKV J3NX05_GAET3/36-85 EKPR....P....CCVCKDEKAKRDECMLFS.....SAKDPE..E...DCTTTIQQYRSCMEGFGFKV Q4WWZ9_ASPFU/27-76 EKPK....P....CCVCKTEKSARDDCMLFS.....KTDDPS..Q...ECKPLIEQYKACMAGYGFKV C5FYY1_ARTOC/31-81 SKPK....P....CCVCKSEKAARDECMLFS.....KSSDPAA.N...ECLQLVQEYKSCMAEFGFKV C0NKR2_AJECG/25-75 SKPK....P....CCVCKTEKAARDDCMLFS.....KSDDAAQ.Q...ECRPLVEQYKSCMAGFGFKI S7ZDG1_PENO1/27-76 EKPK....P....CCVCKDEKAARDDCMLFS.....KSDDPA..K...ECQSLIDQYKSCMLGYGFKV Q0TZC3_PHANO/22-71 QKVK....P....CCVCTEQKAKRDECMLFS.....TSNDAQ..K...ECADLVGQYKQCMAGYGFKI M2LHH3_BAUPA/29-77 AKVK....P....CCVCKDEKSARDECMLFS.....NAADPQ..D...ACKDLVGQYRSCMKTYGFN. R7YJ74_CONA1/24-73 AKVK....P....CCVCKDEKAARDECMLFS.....QSDNAQ..Q...ECRDLVSRYRSCMAGYGFSI K2RNX6_MACPH/29-78 AKPK....P....CCVCKDEKAARDECMLFS.....NSDNAQ..E...ACKDLVSKYKACMAGYGFNI G1XBL7_ARTOA/21-70 DKPK....P....CCVCKPEKSARDECMLKS.....TTDTPE..V...ECKDLIKTYKACMEGFGFKV B3RY56_TRIAD/11-56 KKLR....P....CCACPETKKARDQCMIEK.....G.EA........DCQDLIEAHKDCLRQHGFKV F4S8S2_MELLP/40-93 EGIR....P....CCACPDTKRSRDDCFIRYGPPDESEESS......RRCADLIAAHRACMEQYGFRI A0A0C4F8P0_PUCT1/16-68 .KLK....P....CCACPETKRVRDDCFLRYGPPDESKEST......IKCAELIAAHRACMAQHGFNI D8Q007_SCHCM/13-61 QGLK....P....CCACPQTKRARDDCFLAN.....GAEAD......EKCKELVASHVACMRGLGFNI F8Q700_SERL3/38-87 KGLK....P....CCACPETKSARDACFLQSKT...GGDEG.......ECAELVRRHVECMRSLGFQI I2FPZ3_USTH4/19-73 EGIK....P....CCACPEAKAARDECFFKF.....GHSVEEHGESARKCQDLVKAHRECMAKLGYKV A8PUC8_MALGO/22-76 KGIR....P....CCACPETKAARDDCFLKF.....GHNVEEHGESARKCEELVKRHRECMASLGFKI S8G815_FOMPI/36-85 QGLK....P....CCACPQTKSARDDCFLKHD....SLEVD......EKCKEVVQAHIACMRGYGFKV L8WQ87_THACA/29-79 ...K....PCAEICCACPQTKSERDDCFLRY.....DPSEAPS.....KCADVLQKHIACMRSYGFDV G4TJK8_SERID/30-79 NNLK....P....CCACPETKSARDDCFLKTD....AAVAD......EKCKELVQKHIACMRGYGFNV K5X5K5_AGABU/32-80 EGLK....P....CCACPQTKSLRDDCFLKY.....GDAAP......EQCKEALQNHLACMRSLGFKI V2XBY6_MONRO/32-80 QGLK....P....CCACPQTKSVRDDCFMKY.....GSEAD......EKCQELVQNHLACMRGLGFKI D6RKZ8_COPC7/66-115 EGLK....P....CCACPLTKRARDDCFLKFD....AAEAP......EKCKEQVEKHLACMRSLGFKI I4YH63_WALMC/19-73 EGLK....P....CCVCPETKKLRDECFLFN.....GSNADSSNGSTDACKDVLEAHKACMRSFGFPV Q5KCT7_CRYNJ/40-89 NNLK....P....CCACPETKQARDDCFIKSAP...GEGET.......NCRDFIEAHKACMRGYGFKV F2UKN1_SALR5/17-62 KNMK....P....CCACPETKKPRDKCIMEY.....G.EE........NCYHLIAAHKACMQALGFKI E9G4G5_DAPPU/24-69 KKLK....P....CCACPETKRARDQCIIEN.....G.EE........NCTTLIQDHLSCMRKLGFNI S2J9W3_MUCC1/22-67 KPLK....P....CCACPETKKVRDECIFQK.....G.EE........NCQELIQAHLTCMRNLGFKI A0A068YHI2_ECHMU/14-59 KPLK....P....CCACPDTRKARDECIVER.....G.EE........NCNDLIEAHLTCLRSLGFKI H2XPZ5_CIOIN/33-78 KPLK....P....CCCCPETKTARDECIVNR.....G.EE........ACGDLIQAHKQCLRDLGFNI T1K8S8_TETUR/18-63 KKLK....P....CCACPETKQARDECIIQR.....G.EE........HCHDLIEAHKKCMRDLGFKI G3N946_GASAC/20-65 KPLK....P....CCACPETKKVRDACIIEK.....G.EE........SCAVLIEAHKDCMRALGFKI #=GC seq_cons p+.K....P....CCsC.-pKpsRD-Chlhp.....G.-s........cCpclIcta+sCM+uhGFcl //