# STOCKHOLM 1.0 #=GF ID Cmc1 #=GF AC PF08583.13 #=GF DE Cytochrome c oxidase biogenesis protein Cmc1 like #=GF PI UPF0287; #=GF AU Mistry J;0000-0003-2479-5322 #=GF AU Wood V;0000-0001-6330-7526 #=GF SE manual #=GF GA 22.00 22.00; #=GF TC 22.00 22.00; #=GF NC 21.90 21.90; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq #=GF TP Family #=GF CL CL0351 #=GF RN [1] #=GF RM 18443040 #=GF RT Cmc1p is a Conserved Mitochondrial Twin Cx9C Protein Involved in #=GF RT Cytochrome c Oxidase Biogenesis. #=GF RA Horn D, Al-Ali H, Barrientos A; #=GF RL Mol Cell Biol. 2008; [Epub ahead of print] #=GF DR INTERPRO; IPR013892; #=GF DR SO; 0100021; polypeptide_conserved_region; #=GF CC Cmc1 is a metallo-chaperone like protein which is known to #=GF CC localise to the inner mitochondrial membrane in Saccharomyces #=GF CC cerevisiae. It is essential for full expression of cytochrome c #=GF CC oxidase and respiration [1]. Cmc1 contains two Cx9C motifs and #=GF CC is able to bind copper(I). Cmc1 is thought to play a role in #=GF CC mitochondrial copper trafficking and transfer to cytochrome c #=GF CC oxidase [1]. #=GF SQ 46 #=GS A0E934_PARTE/50-114 AC A0E934.1 #=GS Q4UBH8_THEAN/396-462 AC Q4UBH8.1 #=GS COXM2_HUMAN/1-71 AC Q9NRP2.1 #=GS COXM2_DANRE/1-71 AC Q6DHJ6.1 #=GS COXM2_XENTR/1-70 AC Q28BU7.1 #=GS A4RVT2_OSTLU/1-70 AC A4RVT2.1 #=GS Q0WSU0_ARATH/1-70 AC Q0WSU0.1 #=GS COXM1_SCHPO/1-69 AC O74347.1 #=GS Q6C0R6_YARLI/1-70 AC Q6C0R6.1 #=GS Q6BU65_DEBHA/1-70 AC Q6BU65.1 #=GS A5DP13_PICGU/21-90 AC A5DP13.2 #=GS A5E6F9_LODEL/1-70 AC A5E6F9.1 #=GS Q6CMH5_KLULA/1-70 AC Q6CMH5.1 #=GS COXM2_YEAST/1-68 AC Q3E7A4.1 #=GS A7TQD6_VANPO/1-70 AC A7TQD6.1 #=GS Q75D06_ASHGO/1-70 AC Q75D06.1 #=GS Q4WKF8_ASPFU/64-133 AC Q4WKF8.1 #=GS Q0CNA5_ASPTN/1-70 AC Q0CNA5.1 #=GS Q7SF60_NEUCR/1-70 AC Q7SF60.1 #=GS A7EGH7_SCLS1/1-71 AC A7EGH7.1 #=GS Q5KGI7_CRYNJ/1-71 AC Q5KGI7.1 #=GS Q6FW91_CANGA/26-93 AC Q6FW91.1 #=GS A7TSL0_VANPO/28-96 AC A7TSL0.1 #=GS COXM1_YEAST/31-97 AC P36064.2 #=GS Q753X1_ASHGO/28-95 AC Q753X1.1 #=GS Q6CNI9_KLULA/25-92 AC Q6CNI9.1 #=GS Q6BXB5_DEBHA/33-101 AC Q6BXB5.1 #=GS A5DU96_LODEL/35-104 AC A5DU96.1 #=GS Q5ALU3_CANAL/36-105 AC Q5ALU3.1 #=GS A3LRN0_PICST/36-105 AC A3LRN0.1 #=GS A5DIQ2_PICGU/32-101 AC A5DIQ2.1 #=GS Q9VJJ1_DROME/34-103 AC Q9VJJ1.1 #=GS A7UUS2_ANOGA/43-112 AC A7UUS2.1 #=GS A8X7W7_CAEBR/65-135 AC A8X7W7.1 #=GS Q0IF43_AEDAE/42-111 AC Q0IF43.1 #=GS Q4RFB6_TETNG/20-88 AC Q4RFB6.1 #=GS COXM1_MOUSE/19-87 AC Q9CPZ8.1 #=GS A7RQG2_NEMVE/10-78 AC A7RQG2.1 #=GS Q6C7C2_YARLI/42-109 AC Q6C7C2.1 #=GS Q5KJR5_CRYNJ/12-79 AC Q5KJR5.1 #=GS A6QYA2_AJECN/40-107 AC A6QYA2.1 #=GS A7EKS3_SCLS1/35-102 AC A7EKS3.1 #=GS Q7SDV5_NEUCR/52-119 AC Q7SDV5.2 #=GS Y5933_DICDI/34-109 AC Q552P9.1 #=GS A4RRJ6_OSTLU/15-83 AC A4RRJ6.1 #=GS Q10NU8_ORYSJ/20-85 AC Q10NU8.1 A0E934_PARTE/50-114 LRGLSYAYAR.RKCHKAVNDLLQCEKD.YGSFWAAFDCQAENHDMKECLAHE.............FDVEMDKLRRNMKMN Q4UBH8_THEAN/396-462 VLKSIGASIR.DKCRAEIDEYVNCCS...ENRFINFKCKKESNEMHKCIRHYQKDATT........PEAIRKVMKE.RFE COXM2_HUMAN/1-71 MHPDLSPHLHTEECNVLINLLKECHKN.HNILKFFGYCNDVDRELRKCLKNEYVENRT.......KSREHGIAMRK.KLF COXM2_DANRE/1-71 MHPDLSPHLHTDECNQLITLLKQCHKE.HNVLKFFGTCNDMDRAMRECLRKEYQTKRE.......RSKAHAEEMRR.RLK COXM2_XENTR/1-70 MHPDLSSHLHTDECNVAINLLKKCHSE.NQFLKYFGQCNDFDREMRKCLKKEYEDRRA.......KSRARSEHMKQ.RL. A4RVT2_OSTLU/1-70 MHPPLTLDKH.PICREAVIALKRCHAE.NALGKFLGKCNEEKWTLDACLKEQKLWKSR.......RNLKLARESKA.RLA Q0WSU0_ARATH/1-70 MHPPLTPHRH.PMCLEIIEEFQKCHID.HPIGKFFGECTELKVKLDRCFRQEKAVKRK.......VNFEQSKKLQE.RLK COXM1_SCHPO/1-69 MHPHLDVNNQ.KQCADLIRALEECHK...SFGKFFGECNTIKYELKACLTKDRNDKAR.......LNRENARMRKKVIEE Q6C0R6_YARLI/1-70 MHPQVQEERF.KSCEPLIMALDECHRE.DFVPRAFGLCNDVKQQLTLCLRAARIEHAS.......QNRAKATEKQK.LFA Q6BU65_DEBHA/1-70 MHPQLDRNRF.DPCEKLMDALEECHRQ.EFMKKALGMCNFEKEELTKCLHYTRVNDAN.......DRIRQSKEKQK.KFE A5DP13_PICGU/21-90 MHPQLDRVRF.DTCESLMDALEECHRQ.EFLKQALGSCNFEKDELAKCIHHTRLNDAN.......ERIKRSRERQK.EYE A5E6F9_LODEL/1-70 MHPQLDKNRF.DTCEKLMDALEECHRR.EFIKQCLGLCNYEKDQLAQCLHYTRVGDSK.......ERIKESRQRQK.KWE Q6CMH5_KLULA/1-70 MHPQLEAERF.HSCIDLIQALDKCHRK.EYYKRALGLCNNEKEALSKCLHEARLSGER.......RYILESREKKK.VIE COXM2_YEAST/1-68 MHPQLEAERF.HSCLDFINALDKCHQK.EYYKRIFGLCNNEKDALNKCLKEASLNNKK.......RAVIESRIKRA.D.. A7TQD6_VANPO/1-70 MHPQLEAQRF.YSCAEFIDALERCHEK.EFYKRMFGVCNNEKEALTKCLKETKRTLTI.......KSIEESKAKRK.VIE Q75D06_ASHGO/1-70 MHPQLEAQRF.HSCLDLVQALEKCHQA.DFYKQAFGLCNPEKEALTQCLHNARLEGEK.......YHILANREKRK.EMD Q4WKF8_ASPFU/64-133 LEDRFKTVIE.KNCEEIMTALDECHAR.GFLHKALGNCNDIKRDVNKCLAAERYQRAK.......KNRDQARDNRK.RIE Q0CNA5_ASPTN/1-70 MHSHLHTPHN.ANCEEIMTALDECHAR.GFLHKALGGCNDIKREVNKCLSQERYARAK.......RNRDQARENRK.RIE Q7SF60_NEUCR/1-70 MHPLLHTKDN.AACHDVMVAFEECHAR.GFLWKSMGMCNELKEELAACLRAERFKTQK.......INQSSVADKKA.IIR A7EGH7_SCLS1/1-71 MHHHLWTKDNSAACEEVMAALDECHAR.GFLWKCMGMCNDKKTAVNKCLRAQRLARTA.......ANREAAKVKNE.KIK Q5KGI7_CRYNJ/1-71 MHAFLGNPDRQLACAEFIQALEECHSR.GYLARLVGVCNDQKAALGACLRQERLERTE.......RNRNAAKERTA.KKK Q6FW91_CANGA/26-93 ARTNLKNMAY.KNCDEYVKAMADCAKQ..NGLKCFPACDQQRADMRQCLLFYQTDHYL........DVERDKIVQK.RIA A7TSL0_VANPO/28-96 ARKNLKKFAY.EQCKEYVEAMAACAKA..NGMKVFPACNEQRDRMAECILFYQIDTKY.......LDMEKDKIIEK.KIA COXM1_YEAST/31-97 .RKNLKTETY.KKCANFVQAMADCAKA..NGMKVFPTCDKQRDEMKSCLLFYQTDEKY.......LDGERDKIVLE.KI. Q753X1_ASHGO/28-95 ARKNLKTMAY.EKCSEYVRAMAECSKA..HGLNVFPACDGPKRQMGECLLFYQKDEFL........DAEWDRIVER.KLD Q6CNI9_KLULA/25-92 ARQNLKKFAY.AQCVEYVEAMVECSKI..HGLKLFPACNEPRDAMRKCILSYQKDSNL........DRQRDLIVER.KIE Q6BXB5_DEBHA/33-101 IFERWRKKTF.QRCDELIKKYIECTNS.YSALEGMSKCQTANNEAQGCVAKYQKIEYL........DIERDILIKE.KAE A5DU96_LODEL/35-104 IFERWRKKAF.KQCDEYIRRYVECSNLYRNPVEAMQKCKKVNEASLDCVKQYQKKEYL........EIERDLFIKE.KQE Q5ALU3_CANAL/36-105 VFERWRKRAF.ARCDELINKYIECSNSYSNPVDAVKKCQKINEESLACVAQYQTKEYL........DIEKDLFIKE.KLE A3LRN0_PICST/36-105 IFDRWRKKAF.AKCDDLIKAYVECSNSYKNPFEGIKNCEKFNDAQLACVAQYQKKEYL........DIERDIMIDE.KIA A5DIQ2_PICGU/32-101 IFEKWRKKAF.AKCDDLIRAYIDCSNSYQSPFEAMSKCEKANQASMGCVEKYQQKKYL........DIERDILIKE.KME Q9VJJ1_DROME/34-103 IPKIMRDRAKTEFCSKEVADFQECCKA..SSILMVATCRKQNSALKECLTQWYQNEAF.......KEECKQIYLQE.RAD A7UUS2_ANOGA/43-112 IPKIMRERAKTEKCIPEVKAFEDCCKG..SGLFMVAKCQEQNDALKACSMEWYRNEQF.......KQECTEIYLAE.RSE A8X7W7_CAEBR/65-135 IPNRMNTQIERVECNESYMGLITCFRT.DGAVSGLNTCKPALELFNRCKYDKFHDPAF.......RTKITDEYIAE.RSA Q0IF43_AEDAE/42-111 IPKIMRERAKTEKCIPEVQDFETCCKD..SGLLMAMKCQKQNEALKTCSLRWYNDEQF.......KSECTEIYLAE.RSE Q4RFB6_TETNG/20-88 IPKLMREKAK.ERCAEKVEAFTHCCKE..SGFFMVFKCREENTAMKECLTAHYKDPSF.......FEECKQEYIEE.KLE COXM1_MOUSE/19-87 IPKIIREKAR.ERCSEQVEDFTRCCKD..SGILMVLKCRKENSALKDCLTAYYNDPAF.......YEECKLEYLKE.REE A7RQG2_NEMVE/10-78 IPKLVREKAR.ERCKDLVDEFEKCCKG..RSISMVWHCRKQNTAMKDCLTKNYQDKEL.......FEACRVEYLQK.RRQ Q6C7C2_YARLI/42-109 VREETRRLAR.IACADVLKVFSDCTKG..RTVSMLWACRIEKANMMECMASHSTMEDF........DRARDEFVQK.KAD Q5KJR5_CRYNJ/12-79 IHEAAKKEAL.RSCDDYVKDFADCATG..RTFSLPFMCKTRLNAMQGCMRDYMTQERM........DAMKLDFIAH.RSE A6QYA2_AJECN/40-107 VRDLYYKRVR.GHCAAEIKEFAACAIN..RTVTATWVCRKQRLAMNACMVEHAKPEEE........DRAREEWFTS.REE A7EKS3_SCLS1/35-102 VQEVYHTRVR.SYCAAEIKTFAECALG..RTFTAPFKCREQNRAMNNCMITHATQSEK........DAAREEWFSL.RLQ Q7SDV5_NEUCR/52-119 VRDIFYARVR.RQCTEEIKAFAECALG..RTFSVPFACRAPHRVMNNCMKLHATPAEQ........DAAREEWFAL.RME Y5933_DICDI/34-109 LRQKLKDQSL.KECSSHVAAFADCSKD..KYISVVWECRELQQLMKNCLVEYTTSERLIGMKREWVDASKKRIYEK.RLQ A4RRJ6_OSTLU/15-83 LITLMKERAL.VRCKTAQRTYYECVKG..RTLSVAWACREQARAMSACLSEHTSDATL........ETMKARWTEAGKPS Q10NU8_ORYSJ/20-85 LRSKMKQKAL.KECDFYCSKYAECARG..RTFSVVWQCRKQAKELNDCLHQFTNDAVL........EEMKKAYMVE.Q.. #=GC seq_cons h+pphcpcsh.cpCp-hlpsht-Cppp..pshphhstCpctpcthppCLpptppscph........stpcschhpc.+hc //