# STOCKHOLM 1.0
#=GF ID PilS
#=GF AC PF08805.14
#=GF DE PilS N terminal
#=GF AU Mistry J;0000-0003-2479-5322
#=GF GA 22.0 22.0
#=GF NC 21.6 21.8
#=GF TC 22.1 22.0
#=GF SE pdb_1q5f
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF CL CL0327
#=GF RN [1]
#=GF RM 14500527
#=GF RT The type IVB pili of Salmonella enterica serovar Typhi bind to
#=GF RT the cystic fibrosis transmembrane conductance regulator. 
#=GF RA Tsui IS, Yip CM, Hackett J, Morris C; 
#=GF RL Infect Immun. 2003;71:6049-6050.
#=GF RN [2]
#=GF RM 15159389
#=GF RT NMR structure of a type IVb pilin from Salmonella typhi and its
#=GF RT assembly into pilus. 
#=GF RA Xu XF, Tan YW, Lam L, Hackett J, Zhang M, Mok YK; 
#=GF RL J Biol Chem. 2004;279:31599-31605.
#=GF DR INTERPRO; IPR014911;
#=GF DR SCOP; 1q5f; fa;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Type IV pili are bacterial virulence-associated adhesins that
#=GF CC promote bacterial attachment to host cells.  In Salmonella
#=GF CC typhi, the structural pilin protein PilS interacts with the
#=GF CC cystic fibrosis transmembrane conductance regulator [1]. 
#=GF CC Mutagenesis studies suggest that residues on an alpha-beta loop
#=GF CC and the C terminal disulphide-bonded region of PilS might be
#=GF CC involved in binding specificity of the pilus [2].
#=GF SQ 22
A0A1Y6BYP6.1/67-197  -DTQELASNLTQMVNDTQ.ALYTGA.AGY........TG.LSNSQLLSADAVPVGMQR...SDGsg....gtDVVSPW-.GTVTVA-AN..TSDATR..-FDVAL..ATVPTANCIKLLGS..V....NKA-..VDAAEV...GST.........ALTL---..PLDLSAAT....TACGAS.DSQTVTLT--
G2J7P8.1/51-182      NDNAAEMSNVQALYSALK.D-IKTT.AGYg.....apGT.ELSEAVIAAGSVPGNMTV...HDN........AIQNQWG.GVYALT---..--STGQ..GFTIRD..PDIPDKNCIKIALA..Q....SQAG.qFSSTAI...NGG.........AEMSG--..ALSAADTV....SACAEK.-RNTIAWTSS
G2J840.1/48-182      -KANDEMGELPTIIANIQ.KVFANR.ANF........GG.ATQELFVNQHVFPTDRVV..pQTA........ELANRWG.GAITTSVVTigSSAPNN..GIALTY..EGVPSMECAAVIPQ..M....DEI-..VRIISV...NGT.........QVKADGQ..PADLDAVS....TACNAS.HANEIVY---
A0A2N3PN47.1/90-223  -KTNNEVANFTALVGNIR.SAYYAAgSNY........AG.MTDVTLATSKIAPGPLIR...SGN........SLMSAFN.HPITVAGA-..--GTGT..TFTISY..TSIPDDACVKFLTT..V....WNT-..MSDSTV...AGA.........TSVNGAApaAFSMAGAT....AACNAG.AANVIVFTL-
A0A1C2FYQ3.1/36-152  ---TMGSMEVSMVIGNTK.SLYAGQ.SNF........VG.LNTAAAIQGGVFPADMAP...AGA.......tTATNVWG.GAVHDD---..--ATAT..GFSVTM..DGVPSADCTHVATS..Y....DGTD..LLSVAI...NGA.........VLTP---..PITPSEAG....ADCTVS.----------
W7X3A0.1/55-189      ------VTAIQDLKGQVV.K-YGGR.VGVf.....naAN.SSLAVLVGQGLFPRSVVG..gT-Qa.....apTVTNEWG.GRVTVAVGT..VNTAGD..SIVFTR..TAVPEVGCTLVGTS..M....DDL-..AETVVI...GAT.........TTKTPGA..RSNAAAVN....TACRAGgNNNTMVVTI-
A0A077ZH17.1/216-324 SDNQKELKNLQTIATKMK.A-QKFQ.GQY........TGtDYVKILTESGGLPADMIA...GGN........KAKNAWG.GAVTIKVS-..--SDKY..SYVIES..SNVPKKNCIDLVTS..L....RSSS.mFTKING...NVT.........NKVDP--..--------....------.----------
R5XRK7.1/40-176      -KTNHLIEQLTMLITNIR.NSFIGQ.HDF........SD.INNNLLINIGAVPADMYDhsrASN........DILHAWN.GKVTIFPSE..ASNNKQ.mAFELYV..NNISKNVCIEMVTM..DwgkdPSSG..FTSLYI...GTL.........E-EDI-A..EPQMKDVH....SSADRN.EANGI-----
A0A2N3PLX2.1/59-187  SKAEAEFQLVDGLVNSFR.DVYAGEaYGT........AA.AMITAITHANRLGAAKVL...TTT........TLSNNYS.GSITPTSS-..----GT..SFQLTD..TNIPYADCITILRH..V....PTSG..YTSVQV...GST.........TLTPP--..-VTLDDAT....NSCASG.AVNTIIFTA-
R5XYY3.1/41-179      ---NKVIDQINTISTNVR.TLYSSQ.RNY........GG.LNNGTAIRMALIPSEMYA...ASNksasgsdvEVTNAFG.GNLYIHSVN.qGTGTDN..AYVIAV..DALPKTACVSIATTdwG....GDSGsgLVAMQIktlGADet.....adSLTDLNA..DIDTSGTS....A-----.----------
A0A0A1H458.1/34-159  --VEQTVQDISQVITNARqGFAQSA.NGYa.....nySS.ANAGSLIQAGDFPIDMVR...NGG........I-VDAWG.NAVTFGPT-..--QNNS..EVTLNFggAGLTQDQCVGVATQ..L....S--G..YVSLVI...GGS.........TFTPAN-..PPDHVTAA....QGCSGG.TA--------
I0IM05.1/69-188      -----------EIQTGVK.Q-VASP.GNY.......gSG.DLTSALIASKSVPSNMII...PGN.......tTTLQGPT.GT---SFYT..VTGNYS..TFSITL..AGITSSGCMRTLEQ..T....TTGN.sWYSVSV...NGS.........SVTQP--..-VSVQMAQ....GVCSSG.-SDTITWVS-
A0A2Z6EVS2.1/31-160  --ANTLAMDLNSLIGSVR.TAYS--.GNY........QA.IN-NTALHQGGFFRSLPS..lKDNh.....gaVTISPGN.GVLTVTPSQ..INATGD..AVQYQI..TNLPDITCLPLVTA..L....ARS-..ASRLTI...NTS.........EVKAPGG..QPDPSQIR....--CIG-.DANTLTLV--
R5YAK4.1/40-133      ---NKCIEEIETLSRGIQ.FYFQGQ.RDY........GE.FNYKQAVSFKLIPKDMFK...EGF.......tEATNAYM.GGVDFFYSSltPGDKNK..AFEISF..QGLSRYACVELVRM..N....W---..------...---.........-------..--------....------.----------
A0A2S5KKW5.1/95-199  ------------------.------.---........--.---AN--VTSVLPPALKD..tISG........ATIALNE.GTISLAASS.pTGTAGT.sAFMWTF..TNVSQEFCQKLAVG..L....GSA-..AQAVLS...GTT.........ALSNKTT..GDNLTALEq..dTLCANQaATNTLKM---
A0A2P1PWZ5.1/53-186  -------ELLSQIQVGIK.SEFPNG.GPY........TG.LAVATLAGNQSLPANRL-...NGG........NIKNPIGlGNVTLGVATypPTNTDG..AYTITM..S-MDVASCSKVVAG..V....EGQ-..FERITV...NGT.........AVKDSKG..ASVVAYTKtladTNCQSAtQPTTVVFTN-
Q7VXE3.1/113-200     ------------------.------.---........--.------------------...---........-------.GVISVAPAA..PGGAPPgsAFTLTL..TNVNGAACPALASV..M....QRV-..SDIIAV...QGKagpv.vvknALAVPAL..PYRAQAAQ....AQCVAG.DRNTFVFTA-
A0A7D5N4A9.1/65-140  -----------------K.T-FKGAtSSS........QD.VSMTVLANQGLVPSDFTN...---........ATANPWG.GNITVTSN-..---NAT..EAKITM..SNISESDCTNLKEI..M....QQRG..LSG---...---.........-------..--------....------.----------
A0A2R4XPG4.1/131-219 ------------------.------.---........--.------------------...---........------K.GTVSLLPAT.lPGGVEG.sAFKLVL..TNVNHAACPALAAV..M....QRM-..AVQVKV...GGQgpgqevknsAAIPA-R..EYDPILAD....AQCMAG.DVNTFEFVI-
A0A1U9JYY6.1/127-190 ------------------.------.---........--.------------------...---........-------.---------..-----Q..ELKITL..DKVSHAACPGLSSV..L....QRI-..ANTISV...GSE.........VVKSESK..VYNAAHAQ....KQCERG.DSNTFEFVI-
A0A410P3I6.1/33-127  ----RENAKIHSAAESVK.SLRTAA.ESYiasgnmtyEG.IVISGLQTAGYLPESFSP...TG-........--SNPWG.GDYTVMPN-..--ADPN..KVDISL..TQVSESGAVRLSAL..F....ANSA..------...---.........-------..--------....------.----------
A0A7D5N3U5.1/39-127  --VNDTVSMIQTLRSASE.RWLVSH.PDY........AD.ISVENLQERNLLPSDFG-...---........--KNPFG.GDITIESG-..-NDANN..QIEITV..TKIPVTACKTLLDR..F....KSVG..TS----...---.........-------..--------....------.----------
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