# STOCKHOLM 1.0 #=GF ID MTCP1 #=GF AC PF08991.13 #=GF DE Mature-T-Cell Proliferation I type #=GF PI DUF1903; #=GF AU Mistry J;0000-0003-2479-5322 #=GF AU Sammut SJ;0000-0003-4472-904X #=GF SE pdb_1hp8 #=GF GA 28.90 28.90; #=GF TC 28.90 28.90; #=GF NC 28.80 28.80; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq #=GF TP Domain #=GF CL CL0351 #=GF RN [1] #=GF RM 9405159 #=GF RT Solution structure of human p8MTCP1, a cysteine-rich protein #=GF RT encoded by the MTCP1 oncogene, reveals a new alpha-helical #=GF RT assembly motif. #=GF RA Barthe P, Yang YS, Chiche L, Hoh F, Strub MP, Guignard L, #=GF RA Soulier J, Stern MH, van Tilbeurgh H, Lhoste JM, Roumestand C; #=GF RL J Mol Biol. 1997;274:801-815. #=GF RN [2] #=GF RM 8361760 #=GF RT MTCP-1: a novel gene on the human chromosome Xq28 translocated #=GF RT to the T cell receptor alpha/delta locus in mature T cell #=GF RT proliferations. #=GF RA Stern MH, Soulier J, Rosenzwajg M, Nakahara K, Canki-Klain N, #=GF RA Aurias A, Sigaux F, Kirsch IR; #=GF RL Oncogene. 1993;8:2475-2483. #=GF RN [3] #=GF RM 10850804 #=GF RT Synthesis and NMR solution structure of an alpha-helical hairpin #=GF RT stapled with two disulfide bridges. #=GF RA Barthe P, Rochette S, Vita C, Roumestand C; #=GF RL Protein Sci. 2000;9:942-955. #=GF DR INTERPRO; IPR027179; #=GF DR SO; 0000417; polypeptide_domain; #=GF CC Members of this family adopt a coiled coil structure, with two #=GF CC antiparallel alpha-helices that are tightly strapped together by #=GF CC two disulfide bridges at each end. The protein sequence shows a #=GF CC cysteine motif, required for the stabilisation of the #=GF CC coiled-coil-like structure. Additional inter-helix hydrophobic #=GF CC contacts impart stability to this scaffold [3]. The precise #=GF CC function of this eukaryotic domain is, as yet, unknown [1]. #=GF CC MTCP1 is found in mitochondria. Mature-T-Cell Proliferation) is #=GF CC the first gene unequivocally identified in the group of uncommon #=GF CC leukemias with a mature phenotype [2]. #=GF SQ 41 #=GS E3QEZ6_COLGM/12-73 AC E3QEZ6.1 #=GS H1VXA9_COLHI/13-72 AC H1VXA9.1 #=GS G4MPJ2_MAGO7/12-73 AC G4MPJ2.1 #=GS G4U8W7_NEUT9/12-73 AC G4U8W7.1 #=GS B2AYY1_PODAN/12-74 AC B2AYY1.1 #=GS G2R2E4_THETT/10-71 AC G2R2E4.1 #=GS G2Q1V4_MYCTT/24-85 AC G2Q1V4.1 #=GS F9WYN3_ZYMTI/14-75 AC F9WYN3.1 #=GS E4ZQK7_LEPMJ/13-74 AC E4ZQK7.1 #=GS G2YL31_BOTF4/12-73 AC G2YL31.1 #=GS G1XAE8_ARTOA/14-75 AC G1XAE8.1 #=GS CMC4_YARLI/12-73 AC Q6C4R1.2 #=GS CMC4_CLAL4/11-72 AC C4Y2J3.1 #=GS CMC4_LODEL/13-74 AC A5DUN2.1 #=GS CMC4_DEBHA/10-71 AC B5RTE0.1 #=GS B9SSN8_RICCO/8-64 AC B9SSN8.1 #=GS D8QMQ6_SELML/7-63 AC D8QMQ6.1 #=GS C3ZDQ0_BRAFL/7-64 AC C3ZDQ0.1 #=GS H3B3Z5_LATCH/6-62 AC H3B3Z5.1 #=GS A0A096ML73_PAPAN/6-62 AC A0A096ML73.1 #=GS H9G3Q9_ANOCA/6-62 AC H9G3Q9.1 #=GS D6WI71_TRICA/6-61 AC D6WI71.1 #=GS E2C428_HARSA/6-61 AC E2C428.1 #=GS E1ZV11_CAMFO/6-61 AC E1ZV11.1 #=GS B4QGI7_DROSI/8-63 AC B4QGI7.1 #=GS B0WUV0_CULQU/9-64 AC B0WUV0.1 #=GS CMC4_LACTC/4-65 AC C5E268.1 #=GS C4QZ89_KOMPG/4-65 AC C4QZ89.1 #=GS CMC4_ZYGRC/7-68 AC C5DT65.1 #=GS G8ZN36_TORDC/4-65 AC G8ZN36.1 #=GS CMC4_YEAST/4-65 AC Q3E7A9.1 #=GS G8JNH0_ERECY/154-214 AC G8JNH0.1 #=GS CMC4_SCHPO/3-66 AC G2TRJ8.1 #=GS F4S5P5_MELLP/9-70 AC F4S5P5.1 #=GS B0DC55_LACBS/6-67 AC B0DC55.1 #=GS F8PSX7_SERL3/8-68 AC F8PSX7.1 #=GS Q755I8_ASHGO/30-91 AC Q755I8.1 #=GS E9DID1_COCPS/12-73 AC E9DID1.1 #=GS G3YGH9_ASPNA/3-58 AC G3YGH9.1 #=GS G9N957_HYPVG/7-70 AC G9N957.1 #=GS G3JN33_CORMM/12-76 AC G3JN33.1 E3QEZ6_COLGM/12-73 PCHPLA.CAIQ....DCLTRNGYKEERCQSIIIALYECCEAFYQSKG..DNATTVSCPKPD.LLQLKLRR H1VXA9_COLHI/13-72 IAKPPT.PV......DCLTRNSYKEDRCQSAIMALYECCEAFYRFKG..SQATTVSCPKPD.LLQLKLNR G4MPJ2_MAGO7/12-73 PCHPRA.CAIQ....DCLTKNGYKEEKCQGVIDALYDCCKAFYEKKG..DDASTVSCPKPD.LLRLKIQQ G4U8W7_NEUT9/12-73 PCHPRA.CAIQ....NCLTRNGFDESKCQKQIDALYECCNAFYEKNG..ESASTVSCPKAS.LLRLKMEQ B2AYY1_PODAN/12-74 PCHPRALTGIT....DCLTRNGFDEAKCTRYVDALYECCQAFYKKNG..DEATTVSCPKAS.LLRLKMEQ G2R2E4_THETT/10-71 PCHPRA.CAIQ....NCLTKNGYDEAKCAQFVDALYECCQAFYERNG..DNAATVSCPKPN.LLRLKMEQ G2Q1V4_MYCTT/24-85 GDYTCS.LSSQ....DCLTRNAYNEAKCARFVDALYECCQVFYERNG..EKAVTASCPKPD.LLRLKMEQ F9WYN3_ZYMTI/14-75 PCHPLA.CAIQ....DCIQKNNYDEAKCKKQIDALYECCNLFYKKEG..DDATTVSCPKAS.LLRLKMKQ E4ZQK7_LEPMJ/13-74 PCHPRA.CAIQ....NCIQRNSFNEAKCKKEIDALYECCNAFYKERG..ENASTVSCPKYS.LLILKMKQ G2YL31_BOTF4/12-73 PCHSKA.CAIQ....DCLAKNNYSEEKCRSQVDALYDCCNAFYEKNG..DDATSVSCPKAH.LLRLKMKQ G1XAE8_ARTOA/14-75 ACHSKA.CAIQ....DCIQKNGYNEAKCQDQIDALYACCELFYKRQG..RDARTVSCPKPN.LLDLRIKQ CMC4_YARLI/12-73 PCHAYA.CRIQ....DCLQRSGYNESKCTKLIDELYECCAKFYMSKG..EDARSTSCPKPN.LLKLKIQQ CMC4_CLAL4/11-72 ACKPFA.CAIQ....DCLIENGYNESKCTKAIDNLYKCCKQFYEENG..PDAASVCCPKFN.LLQLKLKQ CMC4_LODEL/13-74 ACQAKA.CAIQ....DCLQGNGYNEAKCTKYIDDLYQCCKNFYEENG..VDAKSVCCPKFK.LLQLKLKQ CMC4_DEBHA/10-71 PCKPEA.CAIQ....DCLQQNNYNESKCSKIIDNLYLCCKKYYEKNG..SDKQTTCCPKFN.LLQLKLKQ B9SSN8_RICCO/8-64 PCKKEA.CDIQ....ACLSKNNFLPQRCLKVIENLQSCCEKCEYK........STHCGSVSSLLKQIPKR D8QMQ6_SELML/7-63 PCNQHA.CDIQ....ACLQRNHYVMESCRQVILNLQKCCDECENR........SKHCAALSGLIAQVTRT C3ZDQ0_BRAFL/7-64 PCQRQA.CDIQ....VCLQANNYKESRCESVLRAMERCCEKPWAQD.......SVCCSGFRKTHRSKTED H3B3Z5_LATCH/6-62 PCQKQA.CEIQ....KCLQANNYLEDKCAHLIREMRKCCAIYSGEN.......SICCSGFR.KENEEKKT A0A096ML73_PAPAN/6-62 PCQKQA.CEIQ....KCLQANNYMESKCQAVIQELRKCCAQYPKGR.......SVVCSGFE.KEEEENLT H9G3Q9_ANOCA/6-62 PCQKYA.CEIQ....KCLQANNYVESKCEAAIQEMRKCCVRYPKGR.......SISCSGFE.SEEKAKQK D6WI71_TRICA/6-61 PCKVFA.CRIQ....KCLEDNKYQESACQHAIEDLHNCCRKWTNQ........SFVCEGIR.IDPAPRKE E2C428_HARSA/6-61 PCKQFA.CKLQ....KCLNDNIYQPSHCQSVIEELRICCKKHTRD........SLVCDGID.ITRQYQHN E1ZV11_CAMFO/6-61 PCKQFA.CKLQ....KCLKDNVYQPSRCEEIIEELRKCCVKHSST........STVCDGID.TSKRYEHN B4QGI7_DROSI/8-63 PCKPNA.CRIQ....ACLTKNHYQEDKCLDVLEAMRQCCLKWHKE........SLCCSGID.LEKTYLPD B0WUV0_CULQU/9-64 PCKVSA.CRIQ....TCLKEHKFDETRCYDVLEAMRQCCLKWHQV........SLCCSGIK.LDRDYLAD CMC4_LACTC/4-65 PCKPQA.CAIQ....GCLTKTGFDESKCSHLIDSLYECCSKFYNERG..ADARTPCCPVPS.LLRLKLEQ C4QZ89_KOMPG/4-65 PCKAQA.CAIQ....DCLKSNRYDESKCTKFIDELYACCSQFYKDNG..EESRTVCCPNPS.LLSLKIKQ CMC4_ZYGRC/7-68 SCKPQA.CAIQ....NCLFSNNYNESRCDQAINDLYRCCEKFYKETN..SKGVTPCCPKPD.LLRTKMTQ G8ZN36_TORDC/4-65 PCKPEA.CAIQ....NCLISSDYKESKCQDLVDQLYRCCDKFYKEDG..KENKSPCCPKPD.LLALKMKQ CMC4_YEAST/4-65 PCQKEA.CAIQ....DCLLSHQYDDAKCAKVIDQLYICCSKFYNDNG..KDSRSPCCPLPS.LLELKMKQ G8JNH0_ERECY/154-214 ACKAEA.CAIQ....ACLKRHGYDEGRCVAAVNELYACCRRFYRGQ...RGGSSSCCPGAE.VVERRVGG CMC4_SCHPO/3-66 DCQKEA.CNLQ....SCIQRNQYNQGNCEKFVNDLLLCCKRWYDKNSLTGNEAPHTCPELK.PLLRQLSS F4S5P5_MELLP/9-70 ICQLEA.CQLQ....KCLNRFTYQPERCEELVKRLYKCCKVMYDENG..DQIKSTACASKE.KVKEKIEK B0DC55_LACBS/6-67 TCQTEA.CDLQ....SCLNRNTYAPEKCEKNLRSLYECCQRFYKLTE..GRGESTSCPLPN.VVQRWMRD F8PSX7_SERL3/8-68 ECQAEA.CALQ....TCLSSNTYSPENCGRQLRGLYLCCKQMYSESE..GKKESSACPMSS.VVERWFK. Q755I8_ASHGO/30-91 PCKAQA.CAIQ....ACLKRTGYEEGRCAAAVEALYTCCAQFYEREG..RDARSVCCPAPD.VVAARRQE E9DID1_COCPS/12-73 PCHSFA.CAIQ....DCLTKNSYQEERCRDQIIALYKCCDLFYQENG..RDARTPSCPRPD.LLKLKLQQ G3YGH9_ASPNA/3-58 LI.......LA....ACLTKNSYQEEKCQSQINALYECCNAFYKARG..EDAKTPSCPKPN.LLRLKMKQ G9N957_HYPVG/7-70 PCHPR...AVTEITPDCLSKNNYNEARCQNAIKALYECCDAFYQRYG..DDATSPSCPAPK.LLRLKIQQ G3JN33_CORMM/12-76 PCHPRA.CAIQGSYSDPMG.NNYNEARCQDVIKALYTCCESFYKRHG..DSASSPSCPKPS.LLRLKMKQ #=GC seq_cons PC+spA.CsIQ....sCLpcNsYsEu+CpchIcsLYcCCppFYccpG..tpupossCPtss.LLchKhcp //